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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2005-8-26
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pubmed:abstractText |
Human cytomegalovirus (HCMV) replication depends on different cellular pathways, including histone acetylation and extracellular-signal regulated kinases 1 and 2 (Erk 1/2). In the present study, the influence of therapeutic valproic acid (VPA) concentrations was investigated on HCMV replication in retinal pigment epithelial (RPE) cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3451-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16123451-Acetylation,
pubmed-meshheading:16123451-Antigens, Viral,
pubmed-meshheading:16123451-Blotting, Western,
pubmed-meshheading:16123451-Cells, Cultured,
pubmed-meshheading:16123451-Cytomegalovirus,
pubmed-meshheading:16123451-Enzyme Inhibitors,
pubmed-meshheading:16123451-Histone Deacetylase Inhibitors,
pubmed-meshheading:16123451-Histones,
pubmed-meshheading:16123451-Humans,
pubmed-meshheading:16123451-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:16123451-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:16123451-Phosphorylation,
pubmed-meshheading:16123451-Pigment Epithelium of Eye,
pubmed-meshheading:16123451-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16123451-Valproic Acid,
pubmed-meshheading:16123451-Virus Replication
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pubmed:year |
2005
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pubmed:articleTitle |
Increased replication of human cytomegalovirus in retinal pigment epithelial cells by valproic acid depends on histone deacetylase inhibition.
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pubmed:affiliation |
Institut für Medizinische Virologie, Klinikum der J. W. Goethe-Universität, Paul-Ehrlich-Strasse 40, 60596 Frankfurt am Main, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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