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pubmed:abstractText |
Exposure to UV-B light (wavelength, 290-320 nm) is a well-documented risk factor for age-related cataracts. As the lens ages, beta-crystallins tend to undergo proteolytic cleavage of their terminal extensions. To delineate the effects of loss of terminal arms on beta-crystallin function, the sensitivity of purified recombinant wild-type (rbetaA3) to UV-irradiation induced aggregation was compared with that of betaA3-crystallin missing the N-terminal extension (rbetaA3tr).
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pubmed:affiliation |
National Eye Institute, National Institutes of Health, Building 10, Room 10B10, 10 Center Drive, Bethesda, MD 20892, USA. sergeev@helix.nih.gov
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