Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2005-12-5
pubmed:abstractText
Cyclin D1 overexpression is believed to be essential in the pathogenesis of mantle cell lymphoma (MCL). Hence, the existence of cyclin D1-negative MCL has been controversial and difficult to substantiate. Our previous gene expression profiling study identified several cases that lacked cyclin D1 expression, but had a gene expression signature typical of MCL. Herein, we report the clinical, pathologic, and genetic features of 6 cases of cyclin D1-negative MCL. All 6 cases exhibited the characteristic morphologic features and the unique gene expression signature of MCL but lacked the t(11;14)(q13; q32) by fluorescence in situ hybridization (FISH) analysis. The tumor cells also failed to express cyclin D1 protein, but instead expressed either cyclin D2 (2 cases) or cyclin D3 (4 cases). There was good correlation between cyclin D protein expression and the corresponding mRNA expression levels by gene expression analysis. Using interphase FISH, we did not detect chromosomal translocations or amplifications involving CCND2 and CCND3 loci in these cases. Patients with cyclin D1-negative MCL were similar clinically to those with cyclin D1-positive MCL. In conclusion, cases of cyclin D1-negative MCL do exist and are part of the spectrum of MCL. Up-regulation of cyclin D2 or D3 may substitute for cyclin D1 in the pathogenesis of MCL.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-10225442, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-10319380, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-10482983, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-10627471, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-10733493, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-10861815, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-11122110, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-11159766, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-11232339, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-11314047, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-11675358, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-12002755, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-12163366, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-12204530, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-12502747, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-12515730, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-12620412, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-12676782, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-12780788, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-12846810, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-12898595, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-12900505, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-1386335, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-14706337, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-15166673, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-1530105, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-1682919, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-7518196, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-7587060, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-7664341, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-7742549, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-8114738, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-8114739, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-8288131, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-8306955, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-8619427, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-8623927, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-8639814, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-8939849, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-8945475, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-9028966, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-9376597, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-9530346, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-9665478, http://linkedlifedata.com/resource/pubmed/commentcorrection/16123218-9713342
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-4971
pubmed:author
pubmed-author:BrazielRita MRM, pubmed-author:ChanWing CWC, pubmed-author:ChiorazziMichaelM, pubmed-author:DaveBhavana JBJ, pubmed-author:DaveSandeepS, pubmed-author:De JongDaphneD, pubmed-author:DelabieJanJ, pubmed-author:FuKaiK, pubmed-author:GascoyneRandy DRD, pubmed-author:GeskStefanS, pubmed-author:GreinerTimothy CTC, pubmed-author:IqbalJaveedJ, pubmed-author:JaffeElaine SES, pubmed-author:KochM FMF, pubmed-author:Lymphoma/Leukemia Molecular Profiling Project, pubmed-author:Müller-HermelinkH KonradHK, pubmed-author:OttGermanG, pubmed-author:RimszaLisaL, pubmed-author:RosenwaldAndreasA, pubmed-author:SangerWarren GWG, pubmed-author:SiebertReinerR, pubmed-author:SmithLynette MLM, pubmed-author:StaudtLouis MLM, pubmed-author:WeisenburgerDennis DDD, pubmed-author:WilsonWyndham HWH, pubmed-author:WrightGeorgeG
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4315-21
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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