Linked Life Data

16122929

Source:http://linkedlifedata.com/resource/pubmed/id/16122929

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2005-11-7
pubmed:abstractText
The antifungal activity of polygodial against Saccharomyces cerevisiae involves multifunctions. Polygodial first acts as a surface-active agent (surfactant) and then becomes involved in biochemical processes. The ability to form a pyrrole derivative with a primary amine group of phosphatidylethanolamine (PE) and phosphatidylserine (PS) in the outer monolayer of the plasma membrane is likely, in part, an initial step in the antifungal action of polygodial. In the lipid fraction derived from cells treated with polygodial, no PE and PS were detected, indicating a disturbance in the balance of the plasma membrane. The primary antifungal action of polygodial comes from its ability to act as a surfactant that nonspecifically disrupts the lipid-protein interface of integral proteins, denaturing their functioned conformation. Once polygodial enters the cytoplasm by destroying the membrane barrier, it reacts with L-cystein-containing cytoplasmic materials, such as a small molecule, glutathione, and a protein, alcohol dehydrogenase, to potentiate the antifungal action.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0968-0896
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6742-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Multifunctional action of antifungal polygodial against Saccharomyces cerevisiae: involvement of pyrrole formation on cell surface in antifungal action.
pubmed:affiliation
Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720-3112, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't