Linked Life Data

16120752

Source:http://linkedlifedata.com/resource/pubmed/id/16120752

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-11-10
pubmed:abstractText
Polybrominated diphenyl ethers (PBDEs), a class of additive flame retardants, are temporally increasing in wildlife tissues and capable of disrupting normal endocrine function. We determined whether in ovo and post-hatch exposure of captive American kestrels (Falco sparverius) to environmentally relevant PBDEs alter thyroid, retinol, and oxidative stress measures. Control eggs were injected with safflower oil and subsequent nestlings fed the same vehicle; dosed eggs received PBDE congeners (BDE-47, -99, -100, -153), which mainly comprise the Penta-BDE commercial mixture, dissolved in safflower oil at concentrations (1500 ng/g total [Sigma] PBDEs) approximating those in Great Lakes gull eggs. Nestlings hatching from dosed eggs were orally exposed for 29 days to variable SigmaPBDE concentrations that are similar to levels reported in tissues of Great Lakes trout (100 ng/g). Treatment kestrels had lower plasma thyroxine (T(4)), plasma retinol, and hepatic retinol and retinyl palmitate concentrations, but unaltered triiodothyronine (T(3)) concentrations and thyroid glandular structure. BDE-47, -100, and -99 were negatively associated with plasma T(4), plasma retinol (BDE-100, -99) and hepatic retinol (BDE-47). Despite an antioxidant-rich diet, PBDE exposure induced hepatic oxidative stress, particularly in females, with an increased hepatic GSSG:GSH ratio, a marginal increase in lipid peroxidation, and increased oxidized glutathione. Positive associations were found between concentrations of BDE-183 and thiols and, in males, between BDE-99 and reduced GSH, but a negative association occurred between BDE-99 and TBARS. Subsequently, concentrations of PBDE congeners in wild birds may alter thyroid hormone and vitamin A concentrations, glutathione metabolism and oxidative stress.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1096-6080
pubmed:author
pubmed:issnType
Print
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
375-83
pubmed:dateRevised
2010-9-17
pubmed:meshHeading
pubmed-meshheading:16120752-Animals, pubmed-meshheading:16120752-Animals, Newborn, pubmed-meshheading:16120752-Environmental Exposure, pubmed-meshheading:16120752-Environmental Monitoring, pubmed-meshheading:16120752-Environmental Pollutants, pubmed-meshheading:16120752-Falconiformes, pubmed-meshheading:16120752-Female, pubmed-meshheading:16120752-Flame Retardants, pubmed-meshheading:16120752-Glutathione, pubmed-meshheading:16120752-Halogenated Diphenyl Ethers, pubmed-meshheading:16120752-Homeostasis, pubmed-meshheading:16120752-Male, pubmed-meshheading:16120752-Ovum, pubmed-meshheading:16120752-Oxidative Stress, pubmed-meshheading:16120752-Phenyl Ethers, pubmed-meshheading:16120752-Polybrominated Biphenyls, pubmed-meshheading:16120752-Thyroid Gland, pubmed-meshheading:16120752-Thyroid Hormones, pubmed-meshheading:16120752-Vitamin A
pubmed:year
2005
pubmed:articleTitle
Exposure to polybrominated diphenyl ethers (PBDEs): changes in thyroid, vitamin A, glutathione homeostasis, and oxidative stress in American kestrels (Falco sparverius).
pubmed:affiliation
Canadian Wildlife Service, Burlington, Ontario. kim.fernie@ec.gc.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't