Linked Life Data

16119242

Source:http://linkedlifedata.com/resource/pubmed/id/16119242

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2005-8-25
pubmed:abstractText
A flat-interface nerve electrode (FINE) is presented as a potential solution for using multifascicle nerve recordings as part of a closed-loop control system. To investigate the ability of this electrode to achieve selective recordings at physiological signal-to-noise ratio (SNR), a finite-element model (FEM) of a beagle hypoglossal nerve with an implanted FINE was constructed. Action potentials (AP) were generated at various SNR levels and the performance of the electrode was assessed with a selectivity index (0 < or = SI < or = 1; ability of the electrode to distinguish two active sources). Computer simulations yielded a selective range (0.05 < or = SI < or = 0.76) that was 1) related to the interfiber distance and 2) used to predict the minimum interfiber distance (0.23 mm < or = d < or = 1.42 mm) for selective recording at each SNR. The SI was further evaluated using recorded compound APs elicited from electrically activating the branches of the beagle hypoglossal nerve. For all experiments (n = 7), the selectivity (SI = 0.45 +/- 0.16) was within the range predicted by the FEM. This study suggests that the FINE can record the activity from a multifasciculated nerve and, more importantly, distinguish neural signals from pairs of fascicles at physiologic SNR.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0018-9294
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1461-9
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Selective recording of the canine hypoglossal nerve using a multicontact flat interface nerve electrode.
pubmed:affiliation
Neural Engineering Center of the Biomedical Engineering Department, Case Western Reserve University, Cleveland, OH 44106, USA. pby2@duke.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Evaluation Studies, Research Support, N.I.H., Extramural