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pubmed-article:16116455pubmed:abstractTextAblation of preBötzinger complex (preBötC) neurons, critical for respiratory rhythm generation, resulted in a progressive, increasingly severe disruption of respiratory pattern, initially during sleep and then also during wakefulness in adult rats. Sleep-disordered breathing is highly prevalent in elderly humans and in some patients with neurodegenerative disease. We propose that sleep-disordered breathing results from loss of preBötC neurons and could underlie death during sleep in these populations.lld:pubmed
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pubmed-article:16116455pubmed:articleTitleSleep-disordered breathing after targeted ablation of preBötzinger complex neurons.lld:pubmed
pubmed-article:16116455pubmed:affiliationDepartment of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, 90095-1763, USA.lld:pubmed
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