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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2005-8-29
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pubmed:abstractText |
Ablation of preBötzinger complex (preBötC) neurons, critical for respiratory rhythm generation, resulted in a progressive, increasingly severe disruption of respiratory pattern, initially during sleep and then also during wakefulness in adult rats. Sleep-disordered breathing is highly prevalent in elderly humans and in some patients with neurodegenerative disease. We propose that sleep-disordered breathing results from loss of preBötC neurons and could underlie death during sleep in these populations.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16116455-10567264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16116455-11528424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16116455-11751180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16116455-12598679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16116455-12902309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16116455-14501208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16116455-14561023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16116455-15575797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16116455-1683005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16116455-2320245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16116455-3212061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16116455-6878980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16116455-7998770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16116455-8797409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16116455-9351134
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1097-6256
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1142-4
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pubmed:dateRevised |
2011-5-13
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pubmed:meshHeading |
pubmed-meshheading:16116455-Animals,
pubmed-meshheading:16116455-Cell Death,
pubmed-meshheading:16116455-Disease Models, Animal,
pubmed-meshheading:16116455-Electroencephalography,
pubmed-meshheading:16116455-Electromyography,
pubmed-meshheading:16116455-Immunohistochemistry,
pubmed-meshheading:16116455-Immunotoxins,
pubmed-meshheading:16116455-Neurons,
pubmed-meshheading:16116455-Polysomnography,
pubmed-meshheading:16116455-Rats,
pubmed-meshheading:16116455-Receptors, Neurokinin-1,
pubmed-meshheading:16116455-Respiratory Center,
pubmed-meshheading:16116455-Ribosome Inactivating Proteins, Type 1,
pubmed-meshheading:16116455-Sleep, REM,
pubmed-meshheading:16116455-Sleep Apnea Syndromes,
pubmed-meshheading:16116455-Substance P,
pubmed-meshheading:16116455-Time Factors,
pubmed-meshheading:16116455-Wakefulness
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pubmed:year |
2005
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pubmed:articleTitle |
Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons.
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pubmed:affiliation |
Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, 90095-1763, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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