Source:http://linkedlifedata.com/resource/pubmed/id/16116445
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
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| pubmed:dateCreated |
2005-8-29
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| pubmed:abstractText |
Termination of a painful or unpleasant event can be rewarding. However, whether the brain treats relief in a similar way as it treats natural reward is unclear, and the neural processes that underlie its representation as a motivational goal remain poorly understood. We used fMRI (functional magnetic resonance imaging) to investigate how humans learn to generate expectations of pain relief. Using a pavlovian conditioning procedure, we show that subjects experiencing prolonged experimentally induced pain can be conditioned to predict pain relief. This proceeds in a manner consistent with contemporary reward-learning theory (average reward/loss reinforcement learning), reflected by neural activity in the amygdala and midbrain. Furthermore, these reward-like learning signals are mirrored by opposite aversion-like signals in lateral orbitofrontal cortex and anterior cingulate cortex. This dual coding has parallels to 'opponent process' theories in psychology and promotes a formal account of prediction and expectation during pain.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1097-6256
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1234-40
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:16116445-Avoidance Learning,
pubmed-meshheading:16116445-Behavior Therapy,
pubmed-meshheading:16116445-Brain,
pubmed-meshheading:16116445-Capsaicin,
pubmed-meshheading:16116445-Conditioning (Psychology),
pubmed-meshheading:16116445-Female,
pubmed-meshheading:16116445-Functional Laterality,
pubmed-meshheading:16116445-Humans,
pubmed-meshheading:16116445-Image Processing, Computer-Assisted,
pubmed-meshheading:16116445-Magnetic Resonance Imaging,
pubmed-meshheading:16116445-Male,
pubmed-meshheading:16116445-Models, Biological,
pubmed-meshheading:16116445-Oxygen,
pubmed-meshheading:16116445-Pain,
pubmed-meshheading:16116445-Pain Management,
pubmed-meshheading:16116445-Pain Measurement,
pubmed-meshheading:16116445-Reward,
pubmed-meshheading:16116445-Statistics, Nonparametric,
pubmed-meshheading:16116445-Time Factors
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Opponent appetitive-aversive neural processes underlie predictive learning of pain relief.
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| pubmed:affiliation |
Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK. bseymour@fil.ion.ucl.ac.uk
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|