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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2005-8-23
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pubmed:abstractText |
Pseudolaric acid B (PAB) is the major bioactive constituent in the root bark of Pseudolarix kaempferi that has been used as an antifungal remedy in traditional Chinese medicine. Previous studies showed that PAB exhibited substantial cytotoxicity. The aims of this study were to elucidate the molecular target of PAB, to examine its mechanism of action, and to evaluate the efficacy of this compound in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6002-11
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16115945-Animals,
pubmed-meshheading:16115945-Antineoplastic Agents,
pubmed-meshheading:16115945-Apoptosis,
pubmed-meshheading:16115945-Binding, Competitive,
pubmed-meshheading:16115945-Binding Sites,
pubmed-meshheading:16115945-Blotting, Western,
pubmed-meshheading:16115945-Cell Cycle Proteins,
pubmed-meshheading:16115945-Cell Division,
pubmed-meshheading:16115945-Cell Line,
pubmed-meshheading:16115945-Cell Line, Tumor,
pubmed-meshheading:16115945-Cell Survival,
pubmed-meshheading:16115945-Colchicine,
pubmed-meshheading:16115945-Diterpenes,
pubmed-meshheading:16115945-Dose-Response Relationship, Drug,
pubmed-meshheading:16115945-Drug Resistance, Multiple,
pubmed-meshheading:16115945-Drug Resistance, Neoplasm,
pubmed-meshheading:16115945-Drugs, Chinese Herbal,
pubmed-meshheading:16115945-G2 Phase,
pubmed-meshheading:16115945-HeLa Cells,
pubmed-meshheading:16115945-Humans,
pubmed-meshheading:16115945-Liver Neoplasms,
pubmed-meshheading:16115945-Male,
pubmed-meshheading:16115945-Mice,
pubmed-meshheading:16115945-Mice, Inbred BALB C,
pubmed-meshheading:16115945-Mice, Nude,
pubmed-meshheading:16115945-Microscopy, Fluorescence,
pubmed-meshheading:16115945-Microtubules,
pubmed-meshheading:16115945-Molecular Structure,
pubmed-meshheading:16115945-Time Factors,
pubmed-meshheading:16115945-Treatment Outcome,
pubmed-meshheading:16115945-Tubulin,
pubmed-meshheading:16115945-Xenograft Model Antitumor Assays
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pubmed:year |
2005
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pubmed:articleTitle |
Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo.
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pubmed:affiliation |
Department of Chemistry, The University of Hong Kong, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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