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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2005-8-23
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pubmed:abstractText |
Mesothelin is a cell surface protein that is highly expressed in some malignant tumors, and is a promising target for immunotherapy. Recent data suggests that mesothelin is an adhesive protein and may have a role in the metastases of ovarian cancer. Although a few monoclonal antibodies (MAb) to mesothelin have been produced, they have limitations for the study of expression of native mesothelin because of their low affinity or reactivity only with denatured mesothelin protein. We have produced novel MAbs to mesothelin to help study mesothelin function and to develop improved diagnosis and immunotherapy of mesothelin-expressing tumors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5840-6
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pubmed:dateRevised |
2011-10-26
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pubmed:meshHeading |
pubmed-meshheading:16115924-Animals,
pubmed-meshheading:16115924-Antibodies, Monoclonal,
pubmed-meshheading:16115924-Antibody Specificity,
pubmed-meshheading:16115924-Blotting, Western,
pubmed-meshheading:16115924-Cell Line,
pubmed-meshheading:16115924-Cell Line, Tumor,
pubmed-meshheading:16115924-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16115924-Female,
pubmed-meshheading:16115924-Flow Cytometry,
pubmed-meshheading:16115924-GPI-Linked Proteins,
pubmed-meshheading:16115924-Humans,
pubmed-meshheading:16115924-Immunoglobulin Fc Fragments,
pubmed-meshheading:16115924-Immunohistochemistry,
pubmed-meshheading:16115924-Membrane Glycoproteins,
pubmed-meshheading:16115924-Mice,
pubmed-meshheading:16115924-Mice, Knockout,
pubmed-meshheading:16115924-Recombinant Fusion Proteins,
pubmed-meshheading:16115924-Reproducibility of Results,
pubmed-meshheading:16115924-Tissue Array Analysis
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pubmed:year |
2005
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pubmed:articleTitle |
New monoclonal antibodies to mesothelin useful for immunohistochemistry, fluorescence-activated cell sorting, Western blotting, and ELISA.
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pubmed:affiliation |
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4264, USA.
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pubmed:publicationType |
Journal Article
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