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rdf:type |
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lifeskim:mentions |
umls-concept:C0004561,
umls-concept:C0015576,
umls-concept:C0021469,
umls-concept:C0034805,
umls-concept:C0162638,
umls-concept:C0205314,
umls-concept:C0679622,
umls-concept:C1444748,
umls-concept:C1704259,
umls-concept:C1704928,
umls-concept:C1705987
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pubmed:issue |
42
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pubmed:dateCreated |
2005-10-17
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pubmed:abstractText |
The inhibitory Fc receptors function to regulate the antigen-driven activation and expansion of lymphocytes. In B cells, the Fc gammaRIIB1 is a potent inhibitor of B cell antigen receptor (BCR) signaling when coligated to the BCR by engagement of antigen-containing immune complexes. Inhibition is mediated by the recruitment of the inositol phosphatase, SHIP, to the Fc gammaRIIB1 phosphorylated tyrosine-based inhibitory motif (ITIM). Here we show that BCR-independent aggregation of the Fc gammaRIIB1 transduces an ITIM- and SHIP-independent proapoptotic signal that is dependent on members of the c-Abl tyrosine kinase family. These results define a novel Abl family kinase-dependent Fc gammaRIIB1 signaling pathway that functions independently of the BCR in controlling antigen-driven B cell responses.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochromes c,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Fc gamma receptor IIB,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Monoester Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-abl,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fc,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgG,
http://linkedlifedata.com/resource/pubmed/chemical/myo-inositol-1 (or...
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
280
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
35247-54
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16115887-Amino Acid Motifs,
pubmed-meshheading:16115887-Animals,
pubmed-meshheading:16115887-Antigens,
pubmed-meshheading:16115887-Antigens, CD,
pubmed-meshheading:16115887-Apoptosis,
pubmed-meshheading:16115887-B-Lymphocytes,
pubmed-meshheading:16115887-Blotting, Western,
pubmed-meshheading:16115887-Caspases,
pubmed-meshheading:16115887-Cell Cycle,
pubmed-meshheading:16115887-Cell Line, Tumor,
pubmed-meshheading:16115887-Chickens,
pubmed-meshheading:16115887-Cytochromes c,
pubmed-meshheading:16115887-Cytoplasm,
pubmed-meshheading:16115887-DNA,
pubmed-meshheading:16115887-Hematopoietic Stem Cells,
pubmed-meshheading:16115887-Immunoprecipitation,
pubmed-meshheading:16115887-In Situ Nick-End Labeling,
pubmed-meshheading:16115887-Membrane Potentials,
pubmed-meshheading:16115887-Mice,
pubmed-meshheading:16115887-Mitochondrial Membranes,
pubmed-meshheading:16115887-Phosphoric Monoester Hydrolases,
pubmed-meshheading:16115887-Phosphorylation,
pubmed-meshheading:16115887-Protein-Tyrosine Kinases,
pubmed-meshheading:16115887-Proto-Oncogene Proteins c-abl,
pubmed-meshheading:16115887-Receptors, Antigen, B-Cell,
pubmed-meshheading:16115887-Receptors, Fc,
pubmed-meshheading:16115887-Receptors, IgG,
pubmed-meshheading:16115887-Signal Transduction
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pubmed:year |
2005
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pubmed:articleTitle |
The B cell inhibitory Fc receptor triggers apoptosis by a novel c-Abl family kinase-dependent pathway.
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pubmed:affiliation |
Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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