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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-8-23
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pubmed:abstractText |
A total of 81 severe aplastic anaemia patients, aged 2-63 years, received human leucocyte antigen-matched related marrow grafts after cyclophosphamide + antithymocyte globulin followed by postgrafting methotrexate + cyclosporin. Median follow-up was 9.2 years. Ninety-six per cent of patients had sustained engraftment, 24% developed acute graft-versus-host disease (GVHD), grade II in all but two patients, and 26% developed chronic GVHD; all surviving patients eventually responded to immunosuppressive therapy. Six patients developed cancer: one fatal lymphoma and five carcinomas (all five patients are now free of cancer). Survival was 88%. The regimen appeared well tolerated and effective in heavily pretreated patients with aplastic anaemia.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0007-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
747-51
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16115132-Adolescent,
pubmed-meshheading:16115132-Adult,
pubmed-meshheading:16115132-Anemia, Aplastic,
pubmed-meshheading:16115132-Antilymphocyte Serum,
pubmed-meshheading:16115132-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:16115132-Bone Marrow Transplantation,
pubmed-meshheading:16115132-Child,
pubmed-meshheading:16115132-Child, Preschool,
pubmed-meshheading:16115132-Cyclophosphamide,
pubmed-meshheading:16115132-Cyclosporine,
pubmed-meshheading:16115132-Female,
pubmed-meshheading:16115132-Follow-Up Studies,
pubmed-meshheading:16115132-Graft vs Host Disease,
pubmed-meshheading:16115132-Humans,
pubmed-meshheading:16115132-Immunosuppressive Agents,
pubmed-meshheading:16115132-Karnofsky Performance Status,
pubmed-meshheading:16115132-Male,
pubmed-meshheading:16115132-Methotrexate,
pubmed-meshheading:16115132-Middle Aged,
pubmed-meshheading:16115132-Multivariate Analysis,
pubmed-meshheading:16115132-Survival Rate,
pubmed-meshheading:16115132-Transplantation, Homologous,
pubmed-meshheading:16115132-Transplantation Conditioning,
pubmed-meshheading:16115132-Treatment Outcome
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pubmed:year |
2005
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pubmed:articleTitle |
Cyclophosphamide and antithymocyte globulin as a conditioning regimen for allogeneic marrow transplantation in patients with aplastic anaemia: a long-term follow-up.
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pubmed:affiliation |
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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