Source:http://linkedlifedata.com/resource/pubmed/id/16114514
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2005-8-23
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| pubmed:abstractText |
Atractylodes macrocephala Koidz (AMK) is well-known as a digestive and tonic material and is widely used in traditional Korean herbal medicines. Previously, we found that protein samples obtained from the medicines could induce a preferential stimulation of type 1, rather than type 2, helper T lymphocytes (Th) immune responses in vitro. Since immune response induction is controlled by the balanced activation between Th1- and Th2-type immune responses, we tested to see whether or not the AMK protein sample could inhibit the ovalbumin (OVA)-mediated allergic diarrhea, whose induction has been known to be mediated by the Th2-type immune responses. The sample treatment markedly stimulated lymphocyte proliferation, antibody production, and cytokine secretion in vitro, showing a preferential stimulation of Th1-type immune responses. In particular, oral administration of the AMK sample suppressed the OVA-mediated allergic diarrhea in mice. The sample treatment also suppressed the OVA-mediated enhanced levels of total immunoglobulin (Ig) E, as well as OVA-specific IgE, which are closely associated with Th2 cell stimulation in mice. Furthermore, the oral treatment of the sample significantly increased gamma interferon (IFN-gamma) production by lymphocytes, isolated from spleen and large intestine of the mice, that had been systematically challenged with OVA. Consequently, the oral administration of AMK protein sample suppressed the OVA-mediated allergic diarrhea by preferential stimulation of the Th1-type immune responses.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Proteins
|
| pubmed:status |
MEDLINE
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| pubmed:issn |
0892-3973
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
331-43
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| pubmed:dateRevised |
2009-5-14
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| pubmed:meshHeading |
pubmed-meshheading:16114514-Administration, Oral,
pubmed-meshheading:16114514-Animals,
pubmed-meshheading:16114514-Antibody Formation,
pubmed-meshheading:16114514-Atractylodes,
pubmed-meshheading:16114514-Diarrhea,
pubmed-meshheading:16114514-Immunoglobulin E,
pubmed-meshheading:16114514-Immunoglobulin G,
pubmed-meshheading:16114514-Interferon-gamma,
pubmed-meshheading:16114514-Interleukin-2,
pubmed-meshheading:16114514-Intestine, Large,
pubmed-meshheading:16114514-Korea,
pubmed-meshheading:16114514-Mice,
pubmed-meshheading:16114514-Mice, Inbred BALB C,
pubmed-meshheading:16114514-Ovalbumin,
pubmed-meshheading:16114514-Plant Extracts,
pubmed-meshheading:16114514-Plant Proteins,
pubmed-meshheading:16114514-Spleen,
pubmed-meshheading:16114514-Th1 Cells,
pubmed-meshheading:16114514-Th2 Cells
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| pubmed:year |
2005
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| pubmed:articleTitle |
Suppression of Th2-type immune response-mediated allergic diarrhea following oral administration of traditional Korean medicine: Atractylodes macrocephala Koidz.
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| pubmed:affiliation |
Division of Biological Sciences and Research Center of Bioactive Materials, Chonbuk National University, Chonju, Korea.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|