Linked Life Data

16114500

Source:http://linkedlifedata.com/resource/pubmed/id/16114500

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2005-8-23
pubmed:abstractText
Synurus deltoides was previously found to possess significant anti-inflammatory activity especially against chronic inflammation, and strong analgesic activity in vivo. In this study, new anti-inflammatory formulation containing S. deltoides extract as a major ingredient was prepared and in vivo activity was evaluated. The plausible action mechanism was also investigated. The new formulation (SAG) contains 1 part of S. deltoides extract, 0.9 part of Angelica gigas extract and 0.9 part of glucosamine sulfate (w/w). SAG inhibited dose-dependently edematic response of arachidonic acid (AA)- and 12-O-tetradecanoyl 13-acetate (TPA)-induced ear edema in mice, which is an animal model of acute inflammation. SAG showed 44.1% inhibition of AA-induced ear edema at an oral dose of 50 mg/kg. In an animal model of chronic inflammation, SAG clearly reduced the edematic response of 7-day model of multiple treatment of TPA (38.1% inhibition at 200 mg/kg/day). Furthermore, SAG (50-800 mg/kg/day) as well as S. deltoides extract (285 mg/kg/day) significantly inhibited prostaglandin E2 production from the skin lesion of the animals of 7-day model. These results were well correlated with in vitro finding that SAG as well as S. deltoides extract reduced cyclooxygenase (COX)-1- and COX-2-induced prostanoid production, measured in mouse bone marrow-derived mast cells. Therefore, these results suggest that SAG possesses anti-inflammatory activity in vivo against acute as well as chronic inflammatory animal models at least in part by inhibition of prostaglandin production through COX-1/COX-2 inhibition. And COX inhibition of SAG is possibly contributed by S. deltoides extract among the ingredients. Although the anti-inflammatory potencies of SAG were less than those of currently used anti-inflammatory drugs, this formulation may have beneficial effect on inflammatory disorders as a neutraceutical.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0253-6269
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
848-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16114500-Acetic Acid, pubmed-meshheading:16114500-Angelica, pubmed-meshheading:16114500-Animals, pubmed-meshheading:16114500-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:16114500-Arachidonic Acid, pubmed-meshheading:16114500-Asteraceae, pubmed-meshheading:16114500-Bone Marrow Cells, pubmed-meshheading:16114500-Cells, Cultured, pubmed-meshheading:16114500-Dose-Response Relationship, Drug, pubmed-meshheading:16114500-Drug Combinations, pubmed-meshheading:16114500-Edema, pubmed-meshheading:16114500-Glucosamine, pubmed-meshheading:16114500-Male, pubmed-meshheading:16114500-Mice, pubmed-meshheading:16114500-Mice, Inbred BALB C, pubmed-meshheading:16114500-Mice, Inbred ICR, pubmed-meshheading:16114500-Pain, pubmed-meshheading:16114500-Plant Extracts, pubmed-meshheading:16114500-Prostaglandin D2, pubmed-meshheading:16114500-Tetradecanoylphorbol Acetate
pubmed:year
2005
pubmed:articleTitle
New anti-inflammatory formulation containing Synurus deltoides extract.
pubmed:affiliation
College of Pharmacy, Kangwon National University, Chunchon 200-701, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't