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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2005-9-1
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pubmed:abstractText |
The microvasculature consists of endothelial cells and their surrounding pericytes. Few studies on the regulatory mechanisms of tumour angiogenesis have focused on pericytes. Here we report the identification of tumour-derived PDGFRbeta (+) (platelet-derived growth factor receptor beta) progenitor perivascular cells (PPCs) that have the ability to differentiate into pericytes and regulate vessel stability and vascular survival in tumours. A subset of PDGFRbeta (+) PPCs is recruited from bone marrow to perivascular sites in tumours. Specific inhibition of PDGFRbeta signalling eliminates PDGFRbeta (+) PPCs and mature pericytes around tumour vessels, leading to vascular hyperdilation and endothelial cell apoptosis in pancreatic islet tumours of transgenic Rip1Tag2 mice.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-10024303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-10375497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-10508235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-11001067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-11022980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-11245452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-11331305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-11344100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-11385629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-11529428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-11668599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-11689883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-11772885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-11891196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-12169633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-12514120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-12598306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-12657432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-12727920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-12778130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-12778164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-12883993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-1361507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-14755687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-15041800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-15059931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-15087390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-15181153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-15191949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-15207813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-15557593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-15588508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-15617474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-7958863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-8391634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-8700875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-8804306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-8915187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-9521897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-9566978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-9853830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113679-9916127
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1465-7392
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
870-9
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:16113679-Animals,
pubmed-meshheading:16113679-Mice,
pubmed-meshheading:16113679-Neoplasms,
pubmed-meshheading:16113679-Blood Vessels,
pubmed-meshheading:16113679-Pancreatic Neoplasms,
pubmed-meshheading:16113679-Female,
pubmed-meshheading:16113679-Male,
pubmed-meshheading:16113679-Tumor Cells, Cultured,
pubmed-meshheading:16113679-Cell Differentiation,
pubmed-meshheading:16113679-Bone Marrow Cells,
pubmed-meshheading:16113679-Cell Survival,
pubmed-meshheading:16113679-Neovascularization, Pathologic,
pubmed-meshheading:16113679-Cell Movement,
pubmed-meshheading:16113679-Cell Communication,
pubmed-meshheading:16113679-Insulinoma,
pubmed-meshheading:16113679-Coculture Techniques,
pubmed-meshheading:16113679-Stem Cells,
pubmed-meshheading:16113679-Apoptosis,
pubmed-meshheading:16113679-Endothelial Cells,
pubmed-meshheading:16113679-Mice, Transgenic
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