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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2005-10-13
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pubmed:abstractText |
Target-derived neurotrophins regulate neuronal survival and growth by interacting with cell-surface tyrosine kinase receptors. The p75 neurotrophin receptor (p75 NTR) is coexpressed with Trk receptors in long-range projection neurons, in which it facilitates neurotrophin binding to Trk and enhances Trk activity. Here, we show that TrkA and TrkB receptors undergo robust ligand-dependent ubiquitination that is dependent on activation of the endogenous Trk activity of the receptors. Coexpression of p75 NTR attenuated ubiquitination of TrkA and TrkB and delayed nerve growth factor-induced TrkA receptor internalization and receptor degradation. These results indicate that p75 NTR may prolong cell-surface Trk-dependent signalling events by negatively regulating receptor ubiquitination.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-10436046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-10908605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-11278445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-11461694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-12055187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-12169297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-12234920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-12676795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-12716928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-12717448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-12842080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-12848932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-12848933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-14570567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-14598373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-14641021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-14673001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-14704953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-15337528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-15753096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-1730579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-7540615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-7679912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-8987823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-9379485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16113645-9857023
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1469-221X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
936-41
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16113645-Animals,
pubmed-meshheading:16113645-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:16113645-Cells, Cultured,
pubmed-meshheading:16113645-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:16113645-Humans,
pubmed-meshheading:16113645-Immunoblotting,
pubmed-meshheading:16113645-Immunoprecipitation,
pubmed-meshheading:16113645-Nerve Growth Factor,
pubmed-meshheading:16113645-Neurons,
pubmed-meshheading:16113645-PC12 Cells,
pubmed-meshheading:16113645-Rats,
pubmed-meshheading:16113645-Receptor, Nerve Growth Factor,
pubmed-meshheading:16113645-Receptor, trkA,
pubmed-meshheading:16113645-Receptor, trkB,
pubmed-meshheading:16113645-Signal Transduction,
pubmed-meshheading:16113645-Transfection,
pubmed-meshheading:16113645-Ubiquitin
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pubmed:year |
2005
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pubmed:articleTitle |
p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation.
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pubmed:affiliation |
Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec H3A 2B4, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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