Linked Life Data

16113439

Source:http://linkedlifedata.com/resource/pubmed/id/16113439

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-8-22
pubmed:abstractText
Structural cells such as airway smooth muscle, myofibroblasts, and fibroblasts play important roles in the pathogenesis of asthma and chronic obstructive pulmonary disease. Although considerable research effort has focused on the effects of steroids on leukocyte function and airway inflammation, few studies have investigated the effects of steroids on structural cell function. There is evidence that structural cells, apart from maintaining the integrity of the bronchial wall, may also participate in airway inflammatory responses. New data suggest that steroids inhibit some but not all proliferative and migratory responses in structural cells. Further, in structural cells the downstream signaling effects altered by glucocorticoids appear to differ from those observed in leukocytes. Therapeutic approaches designed to modulate chemokine and cytokine secretion by structural cells may offer new opportunities to treat diseases characterized by airway obstruction.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1546-3222
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
231-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Effects of corticosteroids on structural cells in asthma and chronic obstructive pulmonary disease.
pubmed:affiliation
Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Medical Center, 421 Curie Boulevard, BRB II/III, Philadelphia, PA 19104-6160, USA. rap@mail.med.upenn.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Review, Research Support, N.I.H., Extramural