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rdf:type |
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lifeskim:mentions |
umls-concept:C0013018,
umls-concept:C0017431,
umls-concept:C0030705,
umls-concept:C0042333,
umls-concept:C0085295,
umls-concept:C0206153,
umls-concept:C0247771,
umls-concept:C0330390,
umls-concept:C0439793,
umls-concept:C0599739,
umls-concept:C0856825,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C2323499
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pubmed:issue |
12
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pubmed:dateCreated |
2005-11-18
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pubmed:abstractText |
We have previously shown that the interleukin 10 (IL-10)/-592*A allele of the recipient is associated with less severe acute graft-versus-host disease (GVHD) and a lower risk of nonrelapse mortality after hematopoietic cell transplantation (HCT) from an HLA-identical sibling. In the present study, we examined variation in the IL-10 receptor beta gene as a further test of the hypothesis that the IL-10 pathway regulates the risk of acute GVHD. A single nucleotide polymorphism (A/G) at cDNA position 238 of the IL-10 receptor beta gene (IL10RB/c238) was genotyped in 953 HC transplant recipients and their HLA-identical sibling donors. IL-10/-592 and IL10RB/c238 genotypes were tested for association with GVHD by multivariable analysis. The IL-10/-592*A allele of the recipient and IL10RB/c238*G allele of the donor were significantly associated with a lower risk of grades III-IV acute GVHD (trend P < .001 and P = .02, respectively). The donor IL10RB/c238*G allele provided protection among patients with the IL-10/-592 A/C or A/A genotypes but not among patients with the high-risk IL-10/-592 C/C genotype. These data suggest an interaction of the patient IL-10/-592 and donor IL10RB/c238 genotypes on risk of GVHD, further supporting the hypothesis that the IL-10 pathway plays an important role in controlling the severity of acute GVHD.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-10366102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-10382951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-10490963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-10556960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-10572111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-10673693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-11197303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-11223972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-11238636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-11244051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-11313392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-11380474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-11520812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-11544434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-11821159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-11986199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-12029063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-12135426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-12163567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-12165436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-12239181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-14657427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-14701704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-15032600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-15044650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-15486071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-1887253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-1940369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-1994250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-2207305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-2804362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-3897863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-7581076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-7687627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-7701586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-7833486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-7905018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-8314576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-8691133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-9293864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-9312047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-9339750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-9780337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16109775-9825821
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3995-4001
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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