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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-8-19
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pubmed:abstractText |
It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2- -derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS)-dependent NO production is impaired. Liver is one of the organs with the highest XOR concentration. This study was designed to determine whether NO2- -derived NO by XOR protects liver against I/R injury in vivo. For its minute amounts and active reactivity, NO can not be detected directly in real time in vivo by this time. We have to prove the above hypothesis indirectly.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1499-3872
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
350-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16109514-Adenosine Triphosphate,
pubmed-meshheading:16109514-Alanine Transaminase,
pubmed-meshheading:16109514-Allopurinol,
pubmed-meshheading:16109514-Animals,
pubmed-meshheading:16109514-Enzyme Inhibitors,
pubmed-meshheading:16109514-Female,
pubmed-meshheading:16109514-Liver,
pubmed-meshheading:16109514-Male,
pubmed-meshheading:16109514-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:16109514-Nitric Oxide,
pubmed-meshheading:16109514-Nitric Oxide Synthase,
pubmed-meshheading:16109514-Nitrites,
pubmed-meshheading:16109514-Peroxidase,
pubmed-meshheading:16109514-Rats,
pubmed-meshheading:16109514-Rats, Wistar,
pubmed-meshheading:16109514-Reperfusion Injury,
pubmed-meshheading:16109514-Survival Analysis,
pubmed-meshheading:16109514-Xanthine Dehydrogenase
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pubmed:year |
2005
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pubmed:articleTitle |
Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia-reperfusion injury.
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pubmed:affiliation |
Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. luliu@public.wh.hb.cn
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pubmed:publicationType |
Journal Article
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