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rdf:type |
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lifeskim:mentions |
umls-concept:C0001613,
umls-concept:C0005528,
umls-concept:C0007776,
umls-concept:C0018358,
umls-concept:C0022655,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0120489,
umls-concept:C0249083,
umls-concept:C0332291,
umls-concept:C0687028,
umls-concept:C0851285,
umls-concept:C1516698
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pubmed:issue |
3
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pubmed:dateCreated |
2005-8-17
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pubmed:abstractText |
Electrolyte and water homeostasis mostly depend on differentially regulated intestinal and renal transport. Guanylin and uroguanylin were proposed as first hormones linking intestinal with renal electrolyte and water transport, which is disturbed in pathophysiology. Guanylate cyclase C is the intestinal receptor for these peptides, but in guanylate cyclase C-deficient mice renal effects are retained. Unlike for the intestine the sites of renal actions and cellular mechanisms of guanylin peptides are still unclear.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Gastrointestinal Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Natriuretic Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipases A,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipases A2,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Guanylate Cyclase-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/enterotoxin receptor,
http://linkedlifedata.com/resource/pubmed/chemical/guanylin,
http://linkedlifedata.com/resource/pubmed/chemical/uroguanylin
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1008-17
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16105031-Animals,
pubmed-meshheading:16105031-Arachidonic Acid,
pubmed-meshheading:16105031-Biological Transport,
pubmed-meshheading:16105031-Calcium,
pubmed-meshheading:16105031-Cell Membrane,
pubmed-meshheading:16105031-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:16105031-Cyclic GMP,
pubmed-meshheading:16105031-Cyclic GMP-Dependent Protein Kinases,
pubmed-meshheading:16105031-Gastrointestinal Hormones,
pubmed-meshheading:16105031-Guanylate Cyclase,
pubmed-meshheading:16105031-Kidney Cortex,
pubmed-meshheading:16105031-Kidney Tubules, Collecting,
pubmed-meshheading:16105031-Male,
pubmed-meshheading:16105031-Mice,
pubmed-meshheading:16105031-Mice, Inbred C57BL,
pubmed-meshheading:16105031-Natriuretic Peptides,
pubmed-meshheading:16105031-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:16105031-Phospholipases A,
pubmed-meshheading:16105031-Phospholipases A2,
pubmed-meshheading:16105031-Potassium,
pubmed-meshheading:16105031-Receptors, Guanylate Cyclase-Coupled,
pubmed-meshheading:16105031-Receptors, Peptide,
pubmed-meshheading:16105031-Signal Transduction
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pubmed:year |
2005
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pubmed:articleTitle |
Uroguanylin and guanylin regulate transport of mouse cortical collecting duct independent of guanylate cyclase C.
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pubmed:affiliation |
Universitätsklinikum Münster, Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Münster, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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