Linked Life Data

16103669

Source:http://linkedlifedata.com/resource/pubmed/id/16103669

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2005-9-12
pubmed:abstractText
The existence of an association between apolipoprotein E (APOE) and Alzheimer's disease (AD) has been reported in several studies. The possession of an ApoE epsilon4 allele is now considered a genetic risk factor for sporadic AD. There has been a growing agreement about the role exerted by the ApoE epsilon4 allele on the neuropsychological profile and the rate of cognitive decline in AD patients. However, a more controversial issue remains about a possible influence of the APOE genotype on acetylcholinesterase inhibitor therapy response in AD patients. In order to address this issue, 81 patients diagnosed as having probable AD were evaluated by a complete neuropsychological test battery at the time of diagnosis (baseline) and after 12-16 months (retest). Patients were divided into two subgroups: (1) treated with donepezil at a dose of 5 mg once a day (n = 41) and (2) untreated (n = 40). Donepezil therapy was started after baseline evaluation. The APOE genotype was determined according to standardized procedures. We evaluated the possible effect of the APOE genotype on the neuropsychological tasks in relation to donepezil therapy. The statistical analysis of the results showed a global worsening of cognitive performances for all AD patients at the retest. Differences in the clinical outcome were analysed in the four subgroups of AD patients for each neuropsychological task. ApoE epsilon4 carriers/treated patients had improved or unchanged scores at retest evaluation for the following tasks: visual and verbal memory, visual attention and inductive reasoning and Mini Mental State Examination. These results indicate an effect of donepezil on specific cognitive domains (attention and memory) in the ApoE epsilon4 carriers with AD. This might suggest an early identification of AD patients carrying at least one epsilon4 allele as responders to donepezil therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1420-8008
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2005 S. Karger AG, Basel.
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
254-61
pubmed:dateRevised
2008-3-24
pubmed:meshHeading
pubmed-meshheading:16103669-Aged, pubmed-meshheading:16103669-Alleles, pubmed-meshheading:16103669-Alzheimer Disease, pubmed-meshheading:16103669-Apolipoprotein E4, pubmed-meshheading:16103669-Apolipoproteins E, pubmed-meshheading:16103669-Attention, pubmed-meshheading:16103669-Cholinesterase Inhibitors, pubmed-meshheading:16103669-Cognition, pubmed-meshheading:16103669-Education, pubmed-meshheading:16103669-Female, pubmed-meshheading:16103669-Gene Frequency, pubmed-meshheading:16103669-Genotype, pubmed-meshheading:16103669-Humans, pubmed-meshheading:16103669-Indans, pubmed-meshheading:16103669-Intelligence Tests, pubmed-meshheading:16103669-Language, pubmed-meshheading:16103669-Male, pubmed-meshheading:16103669-Neuropsychological Tests, pubmed-meshheading:16103669-Piperidines, pubmed-meshheading:16103669-Retrospective Studies
pubmed:year
2005
pubmed:articleTitle
Apolipoprotein E epsilon4 allele differentiates the clinical response to donepezil in Alzheimer's disease.
pubmed:affiliation
Institutes of Neurology, Catholic University of Sacred Heart, School of Medicine, University Hospital A. Gemelli, IT-00168 Rome, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't