Source:http://linkedlifedata.com/resource/pubmed/id/16103454
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2005-8-16
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pubmed:abstractText |
Cutaneous malignant melanomas with histologic evidence of an associated nevus (N+) may have a different risk factor profile from that of melanomas without it (N-). To address this question, a case-only analysis of 932 people with cutaneous malignant melanoma was done to identify etiologic and other factors associated with N+ melanoma. Evidence of an associated nevus was found in 36% of melanomas. N+ melanomas were thinner (Ptrend=0.0009) and more likely to be of the superficial spreading type than other types of melanoma. Subjects with N+ melanomas were younger (Ptrend<0.0001) and reported a higher nevus density on their skin than subjects with N- melanomas [odds ratio (OR), 3.1; 95% confidence interval (CI), 1.6-6.0, for high nevus density versus no nevi]. Indicators of high accumulated sun exposure were less prevalent among subjects with N+ melanomas (OR, 0.3; 95% CI, 0.2-0.4, for melanoma location on the head and neck versus location on trunk; OR, 0.2; 95% CI, 0.1-0.4, for severe solar elastosis adjacent to the melanoma versus no elastosis; OR, 0.2; 95% CI, 0.1-0.4, for lentigo maligna melanoma subtype versus superficial spreading subtype). With the exception of solar elastosis and age, all of the aforementioned variables remained significantly associated with N+ melanomas in multivariate analyses. No associations with self-reported measures of sun exposure, sunburn, or pigmentation phenotype were apparent. Our findings provide some support for the hypothesis of etiologically separate pathways for melanoma, with N+ melanomas appearing less likely to develop in the presence of characteristics suggesting high accumulated sun exposure than N- melanomas. However, it is possible that high UV exposure causes involution of nevi, thus reducing the density of nevi in exposed skin and thereby the probability of N+ melanoma.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1055-9965
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pubmed:author |
pubmed-author:ArmstrongBruce KBK,
pubmed-author:FromLynnL,
pubmed-author:GallagherRichard PRP,
pubmed-author:KlarNeil SNS,
pubmed-author:KrickerAnneA,
pubmed-author:MarrettLoraine DLD,
pubmed-author:McLaughlinJohn RJR,
pubmed-author:PurdueMark PMP,
pubmed-author:for the Genes, Environment, and Melanoma Study Group
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2015-22
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16103454-Adult,
pubmed-meshheading:16103454-Aged,
pubmed-meshheading:16103454-Female,
pubmed-meshheading:16103454-Humans,
pubmed-meshheading:16103454-Male,
pubmed-meshheading:16103454-Melanoma,
pubmed-meshheading:16103454-Middle Aged,
pubmed-meshheading:16103454-Multicenter Studies as Topic,
pubmed-meshheading:16103454-Nevus, Pigmented,
pubmed-meshheading:16103454-Questionnaires,
pubmed-meshheading:16103454-Registries,
pubmed-meshheading:16103454-Skin Neoplasms,
pubmed-meshheading:16103454-Skin Pigmentation,
pubmed-meshheading:16103454-Sunlight
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pubmed:year |
2005
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pubmed:articleTitle |
Etiologic and other factors predicting nevus-associated cutaneous malignant melanoma.
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pubmed:affiliation |
Division of Preventive Oncology, Cancer Care Ontario, Toronto, Canada. purduem@mail.nih.gov
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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