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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
34
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pubmed:dateCreated |
2005-8-24
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pubmed:abstractText |
Transferrin receptor (TfR) has been shown to be significantly overexpressed in different types of cancers. We discovered TfR as a target for gambogic acid (GA), used in traditional Chinese medicine and a previously undiscovered link between TfR and the rapid activation of apoptosis. The binding site of GA on TfR is independent of the transferrin binding site, and it appears that GA potentially inhibits TfR internalization. Down-regulation of TfR by RNA interference decreases sensitivity to GA-induced apoptosis, further supporting TfR as the primary GA receptor. In summary, GA binding to TfR induces a unique signal leading to rapid apoptosis of tumor cells. These results suggest that GA may provide an additional approach for targeting the TfR and its use in cancer therapy.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-10197541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-10531064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-10616904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-10638746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-10748106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-10932094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-11239407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-11966439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-12149472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-12197239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-12538494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-12620239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-12637514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-12773051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-12813137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-12920126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-14534531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-14573526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-14723951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-14769924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-15177502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-15531922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-1988160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-2400993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-4028002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-6313760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-8835458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-9046063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-9721092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16103367-9935208
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
pubmed-author:ArcherShannon PSP,
pubmed-author:CaiSui XiongSX,
pubmed-author:DreweJohnJ,
pubmed-author:EnglishNicole MNM,
pubmed-author:GehlsenKurt RKR,
pubmed-author:GreenDouglas RDR,
pubmed-author:JessenKatayoun AKA,
pubmed-author:JiangSongchunS,
pubmed-author:KasibhatlaShailajaS,
pubmed-author:MaliartchoukSergeiS,
pubmed-author:PonceAnthony EAE,
pubmed-author:QiuLingL,
pubmed-author:SirisomaNilanthaN,
pubmed-author:TsengBenB,
pubmed-author:WangJean YuJY,
pubmed-author:ZhangHan-ZhongHZ
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
12095-100
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16103367-Apoptosis,
pubmed-meshheading:16103367-Binding Sites,
pubmed-meshheading:16103367-Cell Line, Tumor,
pubmed-meshheading:16103367-DNA Primers,
pubmed-meshheading:16103367-Drugs, Chinese Herbal,
pubmed-meshheading:16103367-Fluorescent Antibody Technique,
pubmed-meshheading:16103367-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16103367-Humans,
pubmed-meshheading:16103367-Immunohistochemistry,
pubmed-meshheading:16103367-Microscopy, Electron,
pubmed-meshheading:16103367-Neoplasms,
pubmed-meshheading:16103367-RNA Interference,
pubmed-meshheading:16103367-Receptors, Transferrin,
pubmed-meshheading:16103367-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16103367-Xanthones
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pubmed:year |
2005
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pubmed:articleTitle |
A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid.
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pubmed:affiliation |
Maxim Pharmaceuticals, Inc., 6650 Nancy Ridge Drive, San Diego, CA 92121, USA. skasibhatla@maxim.com
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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