16102599

Source:http://linkedlifedata.com/resource/pubmed/id/16102599

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0004611, umls-concept:C0009450, umls-concept:C0079866, umls-concept:C0441712, umls-concept:C0450254, umls-concept:C1550587
pubmed:issue	4
pubmed:dateCreated	2005-8-16
pubmed:abstractText	Studies on the genetic basis of bacterial pathogenicity have been undertaken for almost 30 years, but the development of new genetic tools in the past 10 years has considerably increased the number of identified virulence factors. Signature-tagged mutagenesis (STM) is one of the most powerful general genetic approaches, initially developed by David Holden and colleagues in 1995, which has now led to the identification of hundreds of new genes requested for virulence in a broad range of bacterial pathogens. We have chosen to present in this review, the most recent and/or most significant contributions to the understanding of the molecular mechanisms of bacterial pathogenicity among over 40 STM screens published to date. We will first briefly review the principle of the method and its major technical limitations. Then, selected studies will be discussed where genes implicated in various aspects of the infectious process have been identified (including tropism for specific host and/or particular tissues, interactions with host cells, mechanisms of survival and persistence within the host, and the crossing of the blood brain barrier). The examples chosen will cover intracellular as well as extracellular Gram-negative and Gram-positive pathogens.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8902526
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0168-6445
pubmed:author	pubmed-author:AutretNicolasN, pubmed-author:CharbitAlainA
pubmed:issnType	Print
pubmed:volume	29
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	703-17
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:16102599-Bacteria, pubmed-meshheading:16102599-Genes, Bacterial, pubmed-meshheading:16102599-Mutagenesis, Site-Directed, pubmed-meshheading:16102599-Virulence
pubmed:year	2005
pubmed:articleTitle	Lessons from signature-tagged mutagenesis on the infectious mechanisms of pathogenic bacteria.
pubmed:affiliation	INSERM U-570, CHU Necker-Enfants Malades, Paris, France.
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't