Linked Life Data

16102573

Source:http://linkedlifedata.com/resource/pubmed/id/16102573

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-8-16
pubmed:abstractText
T-cell clones that can efficiently transfer diabetes to prediabetic nonobese diabetic (NOD) mice provide a powerful approach to dissecting the autoimmune disease process and for investigating immunoregulation. Diabetogenic T-cell clones carried in culture allow for detailed analysis of T-cell effector function and in vivo activity, and thus the contribution of a single clonotype to pathogenesis can be studied. As T cells comprising most or all of the repertoire in T-cell receptor transgenic (TCR-Tg) mice, diabetogenic T-cell clones have led to new variations on the NOD mouse model of autoimmune disease. T-cell clones are being used to screen peptide libraries and proteomic arrays to identify the autoantigens that drive these clones in vivo and to extend our knowledge of the processes that give rise to these antigens. With the identification of peptide agonists and natural ligands, the development of MHC-peptide multimers has been possible. These reagents can track T cells in vivo and thus provide new approaches for disease diagnosis and therapy as well as a versatile set of tools for basic research on how T cells contribute to autoimmune disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2776
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
123-62
pubmed:meshHeading
pubmed-meshheading:16102573-Animals, pubmed-meshheading:16102573-Autoantigens, pubmed-meshheading:16102573-CD4-Positive T-Lymphocytes, pubmed-meshheading:16102573-CD8-Positive T-Lymphocytes, pubmed-meshheading:16102573-Cell Movement, pubmed-meshheading:16102573-Chemokines, pubmed-meshheading:16102573-Clone Cells, pubmed-meshheading:16102573-Cytokines, pubmed-meshheading:16102573-Diabetes Mellitus, Type 1, pubmed-meshheading:16102573-Genes, T-Cell Receptor, pubmed-meshheading:16102573-Humans, pubmed-meshheading:16102573-Mice, pubmed-meshheading:16102573-Mice, Inbred NOD, pubmed-meshheading:16102573-Mice, Transgenic, pubmed-meshheading:16102573-RNA, Messenger, pubmed-meshheading:16102573-Receptors, Chemokine, pubmed-meshheading:16102573-Receptors, Cytokine, pubmed-meshheading:16102573-T-Lymphocytes
pubmed:year
2005
pubmed:articleTitle
Pathogenic T-cell clones in autoimmune diabetes: more lessons from the NOD mouse.
pubmed:affiliation
Department of Immunology, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, National Jewish Medical and Research Center, Denver, Colorado 80206, USA.
pubmed:publicationType
Journal Article, Review