Source:http://linkedlifedata.com/resource/pubmed/id/16102534
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2005-8-16
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| pubmed:abstractText |
Vasopressin modulates many social and nonsocial behaviors, including emotionality. We have previously reported that male mice with a null mutation in the V1a receptor (V1aR) exhibit a profound impairment in social recognition and changes in anxiety-like behavior. Using site-specific injections of a V1aR-specific antagonist, we demonstrate that the lateral septum, but not the medial amygdala, is critical for social recognition. Reexpressing V1aR in the lateral septum of V1aR knockout mice (V1aRKO) using a viral vector resulted in a complete rescue of social recognition. Furthermore, overexpression of the V1aR in the lateral septum of wild-type (wt) mice resulted in a potentiation of social recognition behavior and a mild increase in anxiety-related behavior. These results demonstrate that the V1aR in the lateral septum plays a critical role in the neural processing of social stimuli required for complex social behavior.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
0896-6273
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
18
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| pubmed:volume |
47
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
503-13
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:16102534-Amygdala,
pubmed-meshheading:16102534-Animals,
pubmed-meshheading:16102534-Anxiety Disorders,
pubmed-meshheading:16102534-Behavior, Animal,
pubmed-meshheading:16102534-Female,
pubmed-meshheading:16102534-Genetic Vectors,
pubmed-meshheading:16102534-Habituation, Psychophysiologic,
pubmed-meshheading:16102534-Male,
pubmed-meshheading:16102534-Mice,
pubmed-meshheading:16102534-Mice, Inbred C57BL,
pubmed-meshheading:16102534-Mice, Knockout,
pubmed-meshheading:16102534-Mutation,
pubmed-meshheading:16102534-Receptors, Vasopressin,
pubmed-meshheading:16102534-Recognition (Psychology),
pubmed-meshheading:16102534-Septal Nuclei,
pubmed-meshheading:16102534-Sexual Behavior, Animal,
pubmed-meshheading:16102534-Smell,
pubmed-meshheading:16102534-Social Behavior,
pubmed-meshheading:16102534-Transfection
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| pubmed:year |
2005
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| pubmed:articleTitle |
The V1a vasopressin receptor is necessary and sufficient for normal social recognition: a gene replacement study.
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| pubmed:affiliation |
Department of Psychiatry and The Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30329, USA. alanwithisa@yahoo.com
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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