Linked Life Data

16101830

Source:http://linkedlifedata.com/resource/pubmed/id/16101830

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-8-16
pubmed:abstractText
HLA-B*51 is known to be associated with Behcet's disease (BD) in many ethnic groups. The pathogenic gene, however, may lie close to the HLA-B locus and therefore be in linkage disequilibrium with HLA-B*51. On the basis of the proximity of MIC genes to HLA-B, their expression pattern and their affinity for the activating NKG2D receptor on natural killer (NK) cells and gammadelta T cells, these molecules have been postulated as susceptibility factors in BD. DNA from 56 western European Caucasians with BD and 90 Caucasian controls were analysed by polymerase chain reaction using allele-specific primers for MICA and MICB alleles. An increased allele frequency of MICA*009 was found in the BD patient group (25.0%) when compared with the controls (7.2%). This was associated with a corresponding decrease in MICA*008 in the BD patients (36.6%) compared with the controls (46.7%), which was not significant. MICA*009 was strongly associated with the presence of HLA-B*51 in patients and controls. No significant difference in frequency of MICB alleles was found between patients and controls. Both HLA-B*51 and MICA*009 are strongly associated with BD in a pure Caucasian BD patient group, and the two alleles are in linkage disequilibrium. No MICB allele was found to associate significantly with the disease, an unexpected finding considering the close proximity of the MICA and MICB loci. Our results suggest that while MICB does not influence the development of BD, polymorphisms in MICA may be pathogenic, perhaps through the interaction with NK and gammadelta T cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0001-2815
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
195-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:16101830-Alleles, pubmed-meshheading:16101830-Behcet Syndrome, pubmed-meshheading:16101830-Case-Control Studies, pubmed-meshheading:16101830-DNA, pubmed-meshheading:16101830-DNA Primers, pubmed-meshheading:16101830-European Continental Ancestry Group, pubmed-meshheading:16101830-Gene Frequency, pubmed-meshheading:16101830-Genes, MHC Class I, pubmed-meshheading:16101830-HLA Antigens, pubmed-meshheading:16101830-HLA-B Antigens, pubmed-meshheading:16101830-Haplotypes, pubmed-meshheading:16101830-Histocompatibility Antigens Class I, pubmed-meshheading:16101830-Humans, pubmed-meshheading:16101830-Killer Cells, Natural, pubmed-meshheading:16101830-NK Cell Lectin-Like Receptor Subfamily K, pubmed-meshheading:16101830-Polymorphism, Genetic, pubmed-meshheading:16101830-Receptors, Immunologic, pubmed-meshheading:16101830-Receptors, Natural Killer Cell, pubmed-meshheading:16101830-T-Lymphocytes
pubmed:year
2005
pubmed:articleTitle
Associations of major histocompatibility complex class I chain-related molecule polymorphisms with Behcet's disease in Caucasian patients.
pubmed:affiliation
Clinical Transplantation Laboratory, Guy's Hospital, St. Thomas Street, London SE1 9RT, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't