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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-8-16
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pubmed:abstractText |
Anemic tissue hypoxia can decrease the effects of chemotherapy in bladder cancer. Hypoxia leads to overexpression of hypoxia-inducible factor (HIF) and increased synthesis of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF). Tumor cell survival, invasion and angiogenesis thereby compromise treatment.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimetabolites, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxycytidine,
http://linkedlifedata.com/resource/pubmed/chemical/HIF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/gemcitabine
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3413-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16101157-Antimetabolites, Antineoplastic,
pubmed-meshheading:16101157-Blotting, Western,
pubmed-meshheading:16101157-Carcinoma, Transitional Cell,
pubmed-meshheading:16101157-Cell Growth Processes,
pubmed-meshheading:16101157-Cell Hypoxia,
pubmed-meshheading:16101157-Cell Survival,
pubmed-meshheading:16101157-Deoxycytidine,
pubmed-meshheading:16101157-Dose-Response Relationship, Drug,
pubmed-meshheading:16101157-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16101157-Humans,
pubmed-meshheading:16101157-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:16101157-Oxygen,
pubmed-meshheading:16101157-Transcription Factors,
pubmed-meshheading:16101157-Urinary Bladder Neoplasms,
pubmed-meshheading:16101157-Vascular Endothelial Growth Factor A
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pubmed:articleTitle |
Hyperoxia-induced improvement of the in vitro response to gemcitabine in transitional cell carcinoma.
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pubmed:affiliation |
Department of Urology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. guido.fechner@ukb.uni-bonn.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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