|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2005-8-16
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|
pubmed:abstractText |
Gemcitabine is a pyrimidine nucleoside analog that is clinically active against pancreatic cancer. We have recently demonstrated that p38 MAPK is specifically activated by gemcitabine and that pharmacological blockade of p38 MAPK signaling prevented gemcitabine-induced apoptosis in human pancreatic cancer cells. In this study, we further investigated the implication of p38 MAPK in the cytotoxic action of gemcitabine.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0250-7005
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
25
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3347-53
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:16101149-Adenocarcinoma,
pubmed-meshheading:16101149-Antimetabolites, Antineoplastic,
pubmed-meshheading:16101149-Cell Line, Tumor,
pubmed-meshheading:16101149-Deoxycytidine,
pubmed-meshheading:16101149-Drug Interactions,
pubmed-meshheading:16101149-Enzyme Activation,
pubmed-meshheading:16101149-Enzyme Inhibitors,
pubmed-meshheading:16101149-Humans,
pubmed-meshheading:16101149-Imidazoles,
pubmed-meshheading:16101149-Pancreatic Neoplasms,
pubmed-meshheading:16101149-Pyridines,
pubmed-meshheading:16101149-p38 Mitogen-Activated Protein Kinases
|
|
pubmed:articleTitle |
Activation of p38 mitogen-activated protein kinase is necessary for gemcitabine-induced cytotoxicity in human pancreatic cancer cells.
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|
pubmed:affiliation |
Third Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Hokkaido, Japan.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
