|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2005-12-13
|
|
pubmed:abstractText |
Although influenza infection alone may lead to pneumonia, secondary bacterial infections are a much more common cause of pneumonia. Streptococcus pneumoniae is the most frequently isolated causative pathogen during postinfluenza pneumonia. Considering that S. pneumoniae utilizes the platelet-activating factor receptor (PAFR) to invade the respiratory epithelium and that the PAFR is upregulated during viral infection, we here used PAFR gene-deficient (PAFR-/-) mice to determine the role of this receptor during postinfluenza pneumococcal pneumonia. Viral clearance was similar in wild-type and PAFR-/- mice, and influenza virus was completely removed from the lungs at the time mice were inoculated with S. pneumoniae (day 14 after influenza infection). PAFR-/- mice displayed a significantly reduced bacterial outgrowth in their lungs, a diminished dissemination of the infection, and a prolonged survival. Pulmonary levels of IL-10 and KC were significantly lower in PAFR-/- mice, whereas IL-6 and TNF-alpha were only trendwise lower. These data indicate that the pneumococcus uses the PAFR leading to severe pneumonia in a host previously exposed to influenza A.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1040-0605
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
290
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
L194-9
|
|
pubmed:meshHeading |
pubmed-meshheading:16100290-Animals,
pubmed-meshheading:16100290-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:16100290-Chemokines,
pubmed-meshheading:16100290-Cytokines,
pubmed-meshheading:16100290-Female,
pubmed-meshheading:16100290-Immunity,
pubmed-meshheading:16100290-Influenza A virus,
pubmed-meshheading:16100290-Lung,
pubmed-meshheading:16100290-Mice,
pubmed-meshheading:16100290-Mice, Inbred C57BL,
pubmed-meshheading:16100290-Mice, Knockout,
pubmed-meshheading:16100290-Orthomyxoviridae Infections,
pubmed-meshheading:16100290-Osmolar Concentration,
pubmed-meshheading:16100290-Platelet Membrane Glycoproteins,
pubmed-meshheading:16100290-Pneumonia,
pubmed-meshheading:16100290-Pneumonia, Pneumococcal,
pubmed-meshheading:16100290-Receptors, G-Protein-Coupled,
pubmed-meshheading:16100290-Streptococcus pneumoniae,
pubmed-meshheading:16100290-Survival Analysis
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Involvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia.
|
|
pubmed:affiliation |
Laboratory of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. kvandersluijs@amc.uva.nl
|
|
pubmed:publicationType |
Journal Article
|
