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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-8-15
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pubmed:abstractText |
A complex network of interacting transcription factors plays a critical role in normal pancreatic beta cell function, with mutations in certain transcription factor genes known to cause diabetes. In a recent issue of Cell, Gunton et al.(2005) demonstrate a role for the transcription factor ARNT/HIF1beta (hydrocarbon nuclear receptor translocator/hypoxia-inducible factor 1 beta) in normal beta cell function. ARNT expression is reduced in diabetic human islets and beta cell-specific ARNT knockout mice show the impaired glucose tolerance and abnormal insulin secretion that are characteristic of type 2 diabetes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1550-4131
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
78-80
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16098823-Animals,
pubmed-meshheading:16098823-Aryl Hydrocarbon Receptor Nuclear Translocator,
pubmed-meshheading:16098823-Cells, Cultured,
pubmed-meshheading:16098823-DNA-Binding Proteins,
pubmed-meshheading:16098823-Diabetes Mellitus, Type 2,
pubmed-meshheading:16098823-Gene Expression Regulation,
pubmed-meshheading:16098823-Humans,
pubmed-meshheading:16098823-Insulin,
pubmed-meshheading:16098823-Islets of Langerhans,
pubmed-meshheading:16098823-Mice,
pubmed-meshheading:16098823-Mice, Knockout,
pubmed-meshheading:16098823-Receptors, Aryl Hydrocarbon,
pubmed-meshheading:16098823-Transcription, Genetic,
pubmed-meshheading:16098823-Transcription Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Diabetic pancreatic beta cells ARNT all they should be.
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pubmed:affiliation |
Department of Medicine Washington University School of Medicine St.Louis, Missouri 63110, USA.
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pubmed:publicationType |
Journal Article
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