| pubmed-article:16096061 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16096061 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:16096061 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:16096061 | lifeskim:mentions | umls-concept:C1538138 | lld:lifeskim |
| pubmed-article:16096061 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:16096061 | lifeskim:mentions | umls-concept:C2752244 | lld:lifeskim |
| pubmed-article:16096061 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:16096061 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:16096061 | lifeskim:mentions | umls-concept:C0324483 | lld:lifeskim |
| pubmed-article:16096061 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16096061 | pubmed:dateCreated | 2005-8-12 | lld:pubmed |
| pubmed-article:16096061 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16096061 | pubmed:abstractText | Coordination between cell proliferation and cell death is essential to maintain homeostasis in multicellular organisms. In Drosophila, these two processes are regulated by a pathway involving the Ste20-like kinase Hippo (Hpo) and the NDR family kinase Warts (Wts; also called Lats). Hpo phosphorylates and activates Wts, which in turn, through unknown mechanisms, negatively regulates the transcription of cell-cycle and cell-death regulators such as cycE and diap1. Here we identify Yorkie (Yki), the Drosophila ortholog of the mammalian transcriptional coactivator yes-associated protein (YAP), as a missing link between Wts and transcriptional regulation. Yki is required for normal tissue growth and diap1 transcription and is phosphorylated and inactivated by Wts. Overexpression of yki phenocopies loss-of-function mutations of hpo or wts, including elevated transcription of cycE and diap1, increased proliferation, defective apoptosis, and tissue overgrowth. Thus, Yki is a critical target of the Wts/Lats protein kinase and a potential oncogene. | lld:pubmed |
| pubmed-article:16096061 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16096061 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16096061 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16096061 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16096061 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16096061 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16096061 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:16096061 | pubmed:author | pubmed-author:PanDuojiaD | lld:pubmed |
| pubmed-article:16096061 | pubmed:author | pubmed-author:HuangJianbinJ | lld:pubmed |
| pubmed-article:16096061 | pubmed:author | pubmed-author:BarreraJoseJ | lld:pubmed |
| pubmed-article:16096061 | pubmed:author | pubmed-author:WuShianS | lld:pubmed |
| pubmed-article:16096061 | pubmed:author | pubmed-author:MatthewsKrist... | lld:pubmed |
| pubmed-article:16096061 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16096061 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:16096061 | pubmed:volume | 122 | lld:pubmed |
| pubmed-article:16096061 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16096061 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16096061 | pubmed:pagination | 421-34 | lld:pubmed |
| pubmed-article:16096061 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16096061 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16096061 | pubmed:articleTitle | The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. | lld:pubmed |
| pubmed-article:16096061 | pubmed:affiliation | Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA. | lld:pubmed |
| pubmed-article:16096061 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16096061 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16096061 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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