Linked Life Data

16094997

Source:http://linkedlifedata.com/resource/pubmed/id/16094997

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2005-8-12
pubmed:abstractText
The bacterial mutant inf-3 (lambda) is not inducible and does not form filaments following thymine starvation. Lysogenic induction is neither produced by ultraviolet light (UV) nor promoted by tif-1. This phenotype is due to a mutation infA3 located between 60 and 73 min on the E. coli K12 map. The inf mutant is resistant to X-ray and UV irradiation, in contrast to all other known non-inducible bacterial mutants. It is Rec+ and able to perform host cell reactivation as well as UV-reactivation of phage lambda. After exposure to UV light, its DNA is degraded more than that of the parent and the resumption of DNA synthesis is delayed by 30 min; nevertheless, the cell survival is analogous to that of the parent. The inf mutant is also resistant to thymine starvation, for at least 3 hours. Wild type phage lambda forms clear plaques on a lawn of non-lysogenic inf bacteria; a corresponding low level of lysogenization is found. The capacity of inf bacteria to reproduce phages lambda, T4 or T6 is impaired. No gross defect in DNA transcription has been detected. Nevertheless, this mutant might have a slight alteration in the transcription process or in any other process involved in gene expression. This alteration might affect the regulation of DNA replication and cell division as well as prophage lambda induction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0026-8925
pubmed:author
pubmed:issnType
Print
pubmed:volume
136
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
291-307
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
E. coli K12 inf: a mutant deficient in prophage lambda induction and cell filamentation.
pubmed:affiliation
Laboratoire d'Enzymologie, C.N.R.S. Gif-sur-Yvette, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't