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pubmed-article:16094129pubmed:abstractTextTumor progression has been attributed to the accumulation of DNA damage concurrent with selection of advantageous mutations; this DNA damage may result from failure to maintain genomic integrity or from susceptibility to carcinogens. Glutathione S-transferases (GSTs), enzymes that metabolize many carcinogens, may play a role in preserving genome integrity. The objectives of this study are to assess the relationship of GST genotypes with prognosis, clinicopathologic parameters, and genomic instability in papillary thyroid cancer.lld:pubmed
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pubmed-article:16094129pubmed:articleTitleMolecular prognosticators and genomic instability in papillary thyroid cancer.lld:pubmed
pubmed-article:16094129pubmed:affiliationDepartment of Head and Neck Surgery, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, U.S.A. nestor.rigual@roswellpark.orglld:pubmed
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