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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2005-8-11
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pubmed:abstractText |
Tumor progression has been attributed to the accumulation of DNA damage concurrent with selection of advantageous mutations; this DNA damage may result from failure to maintain genomic integrity or from susceptibility to carcinogens. Glutathione S-transferases (GSTs), enzymes that metabolize many carcinogens, may play a role in preserving genome integrity. The objectives of this study are to assess the relationship of GST genotypes with prognosis, clinicopathologic parameters, and genomic instability in papillary thyroid cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0023-852X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
115
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1479-85
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16094129-Adolescent,
pubmed-meshheading:16094129-Adult,
pubmed-meshheading:16094129-Age Factors,
pubmed-meshheading:16094129-Aged,
pubmed-meshheading:16094129-Aged, 80 and over,
pubmed-meshheading:16094129-Base Sequence,
pubmed-meshheading:16094129-Carcinoma, Papillary,
pubmed-meshheading:16094129-Case-Control Studies,
pubmed-meshheading:16094129-DNA, Neoplasm,
pubmed-meshheading:16094129-Disease Progression,
pubmed-meshheading:16094129-Female,
pubmed-meshheading:16094129-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16094129-Genomic Instability,
pubmed-meshheading:16094129-Glutathione Transferase,
pubmed-meshheading:16094129-Humans,
pubmed-meshheading:16094129-Male,
pubmed-meshheading:16094129-Middle Aged,
pubmed-meshheading:16094129-Molecular Sequence Data,
pubmed-meshheading:16094129-Neoplasm Recurrence, Local,
pubmed-meshheading:16094129-Neoplasm Staging,
pubmed-meshheading:16094129-Polymerase Chain Reaction,
pubmed-meshheading:16094129-Probability,
pubmed-meshheading:16094129-Prognosis,
pubmed-meshheading:16094129-Prospective Studies,
pubmed-meshheading:16094129-Reference Values,
pubmed-meshheading:16094129-Risk Assessment,
pubmed-meshheading:16094129-Sensitivity and Specificity,
pubmed-meshheading:16094129-Sex Factors,
pubmed-meshheading:16094129-Smoking,
pubmed-meshheading:16094129-Statistics, Nonparametric,
pubmed-meshheading:16094129-Survival Analysis,
pubmed-meshheading:16094129-Thyroid Neoplasms,
pubmed-meshheading:16094129-Tumor Markers, Biological
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pubmed:year |
2005
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pubmed:articleTitle |
Molecular prognosticators and genomic instability in papillary thyroid cancer.
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pubmed:affiliation |
Department of Head and Neck Surgery, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, U.S.A. nestor.rigual@roswellpark.org
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pubmed:publicationType |
Journal Article,
Comparative Study
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