To determine the effects of age and dual endothelin (ET)A/ETB receptor antagonism (bosentan) on aortic matrix metalloproteinase (MMP) abundance and tissue inhibitor of metalloproteinase (TIMP) expression in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR).
Department of Pharmacology and Therapeutics, Trinity Centre for Health Sciences, Trinity College Dublin, St. James's Hospital, James's Street, Dublin 8, Ireland. spiersj@tcd.ie
