16092794

Source:http://linkedlifedata.com/resource/pubmed/id/16092794

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0035820, umls-concept:C0277785, umls-concept:C0670896, umls-concept:C0702166
pubmed:issue	2
pubmed:dateCreated	2005-8-11
pubmed:abstractText	Acne vulgaris is a common cutaneous disorder of the pilosebaceous follicle, affecting more than 45 million people in the United States alone. The pathogenesis of acne is multifactorial, involving abnormal hyperkeratinization, increased sebum production, hormones, cutaneous microbes, and immunological mechanisms. Many of the immunological processes that contribute to the formation of acne lesions take place at the very site of disease, the skin. Skin is an important component of the innate immune system, providing both physical barriers and rapid cellular responses by keratinocytes, Langerhans cells, and other infiltrating inflammatory cells. In this review, we discuss the ability of the innate immune system to use Toll-like receptors (TLRs) to recognize microbial patterns and initiate immune responses in cutaneous disorders. Because TLRs are vital players in infectious and inflammatory diseases, they are potential therapeutic targets. Indeed, the ability of TLRs to combat disease already has been harnessed through the development of drugs that act as TLR agonists. A better understanding of TLRs will allow for the development of new therapeutic options for cutaneous inflammatory diseases such as acne.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9617260
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	1085-5629
pubmed:author	pubmed-author:KimJennyJ, pubmed-author:McInturffJamie EJE
pubmed:issnType	Print
pubmed:volume	24
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	73-8
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:16092794-Acne Vulgaris, pubmed-meshheading:16092794-Humans, pubmed-meshheading:16092794-Immunity, Innate, pubmed-meshheading:16092794-Skin, pubmed-meshheading:16092794-Toll-Like Receptors
pubmed:year	2005
pubmed:articleTitle	The role of toll-like receptors in the pathophysiology of acne.
pubmed:affiliation	Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 90095, USA.
pubmed:publicationType	Journal Article, Review