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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2005-10-20
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pubmed:abstractText |
Pancreatic ductal adenocarcinoma is an aggressive smoking-associated human cancer in both men and women. The nicotine-derived 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is thought to contribute to the development of these neoplasms in smokers through genotoxic effects. However, NNK has been recently identified as an agonist for both beta(1)- and beta(2)-adrenergic receptors. Binding of NNK to these receptors stimulates proliferation of pulmonary and pancreatic adenocarcinomas cells in vitro and in hamster models. The goal of this study was to elucidate the NNK effects on the signal transduction pathways downstream of both beta(1)- and beta(2)-adrenergic receptors in immortalized human pancreatic HPDE6-c7 cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-(N-methyl-N-nitrosamino)-1-(3-pyri...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrosamines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-2
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0171-5216
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
639-48
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16091975-Adrenergic beta-Agonists,
pubmed-meshheading:16091975-Blotting, Western,
pubmed-meshheading:16091975-Carcinogens,
pubmed-meshheading:16091975-Carcinoma, Pancreatic Ductal,
pubmed-meshheading:16091975-Cell Line, Transformed,
pubmed-meshheading:16091975-Cell Proliferation,
pubmed-meshheading:16091975-Cyclic AMP,
pubmed-meshheading:16091975-Epithelium,
pubmed-meshheading:16091975-Humans,
pubmed-meshheading:16091975-Isoproterenol,
pubmed-meshheading:16091975-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:16091975-Nitrosamines,
pubmed-meshheading:16091975-Pancreatic Ducts,
pubmed-meshheading:16091975-Pancreatic Neoplasms,
pubmed-meshheading:16091975-Phosphorylation,
pubmed-meshheading:16091975-Receptor, Epidermal Growth Factor,
pubmed-meshheading:16091975-Receptors, Adrenergic, beta-2,
pubmed-meshheading:16091975-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16091975-Signal Transduction,
pubmed-meshheading:16091975-Tobacco,
pubmed-meshheading:16091975-Transcriptional Activation
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pubmed:year |
2005
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pubmed:articleTitle |
The tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone stimulates proliferation of immortalized human pancreatic duct epithelia through beta-adrenergic transactivation of EGF receptors.
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pubmed:affiliation |
Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, 37996, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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