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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2005-9-8
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pubmed:abstractText |
Inflammation is a hallmark of acute lung injury and chronic airway diseases. In chronic airway diseases, it is associated with profound tissue remodeling. Peroxisome proliferator-activated receptor-alpha (PPARalpha) is a ligand-activated transcription factor, that belongs to the nuclear receptor family. Agonists for PPARalpha have been recently shown to reduce lipopolysaccharide (LPS)- and cytokine-induced secretion of matrix metalloproteinase-9 (MMP-9) in human monocytes and rat mesangial cells, suggesting that PPARalpha may play a beneficial role in inflammation and tissue remodeling.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-10330027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-10340927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-10415057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-10419448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-10529898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-10542237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-10623622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-10712992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-10936484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-11339500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-11375115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-11851881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-11907182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-11929485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-11940253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-12093797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-12236317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-12495928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-12518001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-12746235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-12755372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-12867511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-12900517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-14563354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-14582923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-1497900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-15293600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-1645657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-2033076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-7539101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-7811465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-7995953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-8596051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-8895578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-8900274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-9374109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-9748221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16091136-9847290
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-993X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
91
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16091136-Animals,
pubmed-meshheading:16091136-Chemotactic Factors,
pubmed-meshheading:16091136-Cytokines,
pubmed-meshheading:16091136-Down-Regulation,
pubmed-meshheading:16091136-Lipopolysaccharides,
pubmed-meshheading:16091136-Male,
pubmed-meshheading:16091136-Matrix Metalloproteinases,
pubmed-meshheading:16091136-Mice,
pubmed-meshheading:16091136-Mice, Inbred C57BL,
pubmed-meshheading:16091136-Mice, Knockout,
pubmed-meshheading:16091136-PPAR alpha,
pubmed-meshheading:16091136-Pneumonia
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pubmed:year |
2005
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pubmed:articleTitle |
PPARalpha downregulates airway inflammation induced by lipopolysaccharide in the mouse.
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pubmed:affiliation |
EA 3771, Inflammation et Environnement dans l'Asthme, Faculté de Pharmacie, Université Louis Pasteur-Strasbourg I, Illkirch, France. orthez@pharma.u-strasbg.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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