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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1992-7-21
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pubmed:abstractText |
Macrophages are thought to play an important role in the pathologic changes associated with idiopathic pulmonary fibrosis (IPF). The mechanisms for increased monocyte/macrophage recruitment in IPF are unknown. Monocyte chemoattractant protein 1 (MCP-1) is the predominant monocyte chemoattractant secreted by a variety of different cell types in culture. We examined the expression of MCP-1 mRNA and its protein product in vivo in IPF and non-IPF lung specimens by in situ hybridization and immunocytochemistry. The cell types expressing MCP-1 in vivo were identified by immunostaining with specific antibodies. We demonstrated the expression of MCP-1 mRNA in pulmonary epithelial cells, in monocytes/macrophages, and in vascular endothelial and smooth muscle cells. Lung epithelial cells in patients with IPF strongly expressed MCP-1 mRNA and its protein product. In contrast, epithelial cells in non-IPF specimens did not express MCP-1 mRNA. Macrophages and vascular endothelial and smooth muscle cells were shown to express MCP-1 in both IPF and non-IPF lung specimens. These findings provide a basis for the understanding of the in vivo physiologic processes that mediate monocyte/macrophage recruitment and infiltration in the lung interstitium and the pathologic state contributing to an increased alveolar monocyte/macrophage population and inflammation in IPF.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-1695010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-1846446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-2113354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-2121752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-2170444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-2313097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-2406243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-2435682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-2465924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-2513477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-2781291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-2787988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-2919636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-3415979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-3522217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-3543052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-3600711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-6183346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-6191602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-6630527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-6839345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-6872001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-7140934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-7227337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1608944-7382428
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5371-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1608944-Arteries,
pubmed-meshheading:1608944-Biopsy,
pubmed-meshheading:1608944-Chemokine CCL2,
pubmed-meshheading:1608944-Chemotactic Factors,
pubmed-meshheading:1608944-Endothelium, Vascular,
pubmed-meshheading:1608944-Epithelium,
pubmed-meshheading:1608944-Humans,
pubmed-meshheading:1608944-Lung,
pubmed-meshheading:1608944-Muscle, Smooth, Vascular,
pubmed-meshheading:1608944-Nucleic Acid Hybridization,
pubmed-meshheading:1608944-Pulmonary Circulation,
pubmed-meshheading:1608944-Pulmonary Fibrosis,
pubmed-meshheading:1608944-RNA, Messenger,
pubmed-meshheading:1608944-RNA Probes
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pubmed:year |
1992
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pubmed:articleTitle |
Expression of monocyte chemoattractant protein 1 mRNA in human idiopathic pulmonary fibrosis.
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pubmed:affiliation |
Center for Blood Research, Harvard School of Public Health, Boston, MA 02115.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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