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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
29
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pubmed:dateCreated |
2005-10-7
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pubmed:abstractText |
Ovarian serous borderline tumors (SBT) are characterized by arborizing papillae lined by stratified epithelial cells, varying atypia, and absence of stromal invasion. Originally, these tumors have been classified as borderline because they behaved in a remarkably indolent manner, even with widespread tumor deposits called implants and the presence of lymph node involvement. The molecular biology of these lesions has just begun to be explored. High prevalence of B-RAF/K-RAS mutations in SBTs in contrast to serous carcinomas (SCAs) indicates that the mitogenic RAS-RAF-MEK-ERK-MAP kinase pathway is crucial for the pathogenesis of SBTs. The purpose of this study was to further unravel the genetic pathways through which SBTs develop, with a special focus on explaining the generally benign SBT behavior. Materials and
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0732-183X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7257-64
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16087957-Dual-Specificity Phosphatases,
pubmed-meshheading:16087957-Female,
pubmed-meshheading:16087957-Gene Expression,
pubmed-meshheading:16087957-Gene Expression Profiling,
pubmed-meshheading:16087957-Genes, Tumor Suppressor,
pubmed-meshheading:16087957-Genes, ras,
pubmed-meshheading:16087957-Humans,
pubmed-meshheading:16087957-Matrix Metalloproteinase 9,
pubmed-meshheading:16087957-Mitogen-Activated Protein Kinase Phosphatases,
pubmed-meshheading:16087957-Mutation,
pubmed-meshheading:16087957-Neoplasms, Cystic, Mucinous, and Serous,
pubmed-meshheading:16087957-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:16087957-Ovarian Neoplasms,
pubmed-meshheading:16087957-Protein C Inhibitor,
pubmed-meshheading:16087957-Protein Tyrosine Phosphatases,
pubmed-meshheading:16087957-Proto-Oncogene Proteins B-raf
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pubmed:year |
2005
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pubmed:articleTitle |
Differential gene expression in ovarian tumors reveals Dusp 4 and Serpina 5 as key regulators for benign behavior of serous borderline tumors.
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pubmed:affiliation |
Department of Pathology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, the Netherlands. nathalie.sieben@path.unimaas.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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