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rdf:type |
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lifeskim:mentions |
umls-concept:C0001625,
umls-concept:C0010481,
umls-concept:C0017262,
umls-concept:C0030705,
umls-concept:C0061126,
umls-concept:C0086418,
umls-concept:C0178539,
umls-concept:C0185117,
umls-concept:C1314939,
umls-concept:C1335671,
umls-concept:C1514559,
umls-concept:C1566330,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2005-8-9
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pubmed:abstractText |
The best characterized effect of glucose-dependent insulinotropic polypeptide (GIP) is its stimulatory effect on insulin secretion by pancreatic beta-cells. Recently, it was demonstrated that some cases of primary adrenal Cushing's syndrome were secondary to the ectopic expression of non-mutated GIP receptor (GIP-R) in bilateral adrenal hyperplasias or unilateral adrenal adenomas, resulting in food-dependent steroidogenesis. Using a human multiple-expression tissue array, GIP-R was found to be expressed in a large number of human adult and fetal tissues, but not in the adrenal gland. The analysis of the promoter region of human (h) GIP-R gene revealed six consensus sequences important in regulating the reporter gene activity and capable of binding to Sp1 and Sp3 transcription factors. Data obtained by gene array and semi-quantitative RT-PCR showed an increase in the expression of Sp3 and CRSP9 (co-regulator of Sp1 transcription factor, subunit 9) in the adrenal adenomas or bilateral macronodular hyperplasias of patients with GIP-dependent Cushing's syndrome; they were, however, also increased in some patients with non-GIP-dependent cortisol-secreting adenomas or with ACTH-dependent Cushing's disease. This study represents the first step in our understanding of the mechanisms involved in the regulation of the expression of the hGIP-R gene.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MED7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mediator Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Gastrointestinal Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/SP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Sp1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Sp3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/gastric inhibitory polypeptide...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0952-5041
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
61-71
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16087722-Adrenal Glands,
pubmed-meshheading:16087722-Adult,
pubmed-meshheading:16087722-Base Sequence,
pubmed-meshheading:16087722-Binding Sites,
pubmed-meshheading:16087722-Case-Control Studies,
pubmed-meshheading:16087722-Consensus Sequence,
pubmed-meshheading:16087722-Cushing Syndrome,
pubmed-meshheading:16087722-DNA,
pubmed-meshheading:16087722-DNA-Binding Proteins,
pubmed-meshheading:16087722-Fetus,
pubmed-meshheading:16087722-Gene Expression,
pubmed-meshheading:16087722-Genes, Reporter,
pubmed-meshheading:16087722-Humans,
pubmed-meshheading:16087722-Mediator Complex,
pubmed-meshheading:16087722-Molecular Sequence Data,
pubmed-meshheading:16087722-Promoter Regions, Genetic,
pubmed-meshheading:16087722-Receptors, Gastrointestinal Hormone,
pubmed-meshheading:16087722-Sp1 Transcription Factor,
pubmed-meshheading:16087722-Sp3 Transcription Factor,
pubmed-meshheading:16087722-Tissue Distribution,
pubmed-meshheading:16087722-Trans-Activators,
pubmed-meshheading:16087722-Transcription Factors,
pubmed-meshheading:16087722-Transfection
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pubmed:year |
2005
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pubmed:articleTitle |
The Sp transcription factors are involved in the cellular expression of the human glucose-dependent insulinotropic polypeptide receptor gene and overexpressed in adrenals of patients with Cushing's syndrome.
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pubmed:affiliation |
Laboratory of Endocrine Pathophysiology, Department of Medicine, Centre Hospitalier de l'Université de Montréal, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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