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pubmed-article:16086866pubmed:abstractTextRecent studies showed that somatic mutations in epidermal growth factor receptor (EGFR) tyrosine kinase (TK) domain are associated with sensitivity of non-small cell lung cancer(NSCLC) to TK inhibitor gefitinib. The mutations, including in-frame deletions at exon 19 and substitutions at exon 18 or exon 21, cluster around ATP-binding pocket of TK domain. The frequency of mutations are higher in Japanese patients than in American patients. This study was to analyze EGFR mutations in Chinese patients with NSCLC.lld:pubmed
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pubmed-article:16086866pubmed:articleTitle[Epidermal growth factor receptor mutation in Chinese patients with non-small cell lung cancer].lld:pubmed
pubmed-article:16086866pubmed:affiliationSkate Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.lld:pubmed
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