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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2005-8-9
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pubmed:abstractText |
Recent studies showed that somatic mutations in epidermal growth factor receptor (EGFR) tyrosine kinase (TK) domain are associated with sensitivity of non-small cell lung cancer(NSCLC) to TK inhibitor gefitinib. The mutations, including in-frame deletions at exon 19 and substitutions at exon 18 or exon 21, cluster around ATP-binding pocket of TK domain. The frequency of mutations are higher in Japanese patients than in American patients. This study was to analyze EGFR mutations in Chinese patients with NSCLC.
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pubmed:language |
chi
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1000-467X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
919-23
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16086866-Adenocarcinoma,
pubmed-meshheading:16086866-Adult,
pubmed-meshheading:16086866-Aged,
pubmed-meshheading:16086866-Amino Acid Substitution,
pubmed-meshheading:16086866-Asian Continental Ancestry Group,
pubmed-meshheading:16086866-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:16086866-China,
pubmed-meshheading:16086866-DNA, Neoplasm,
pubmed-meshheading:16086866-DNA Mutational Analysis,
pubmed-meshheading:16086866-European Continental Ancestry Group,
pubmed-meshheading:16086866-Exons,
pubmed-meshheading:16086866-Female,
pubmed-meshheading:16086866-Humans,
pubmed-meshheading:16086866-Lung Neoplasms,
pubmed-meshheading:16086866-Male,
pubmed-meshheading:16086866-Middle Aged,
pubmed-meshheading:16086866-Mutation,
pubmed-meshheading:16086866-Receptor, Epidermal Growth Factor,
pubmed-meshheading:16086866-Smoking
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pubmed:year |
2005
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pubmed:articleTitle |
[Epidermal growth factor receptor mutation in Chinese patients with non-small cell lung cancer].
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pubmed:affiliation |
Skate Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.
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pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
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