|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2005-9-13
|
|
pubmed:abstractText |
Ionizing radiation induced acute cell death in the dentate gyrus subgranular zone (SGZ) and the subventricular zone (SVZ). Hypomyelination was also observed. The effects of mild hypothermia and hyperthermia for 4 h after irradiation (IR) were studied in postnatal day 9 rats. One hemisphere was irradiated with a single dose of 8 Gy and animals were randomized to normothermia (rectal temperature 36 degrees C for 4 h), hypothermia (32 degrees C for 4 h) or hyperthermia (39 degrees C for 4 h). Cellular injury, e.g. chromatin condensation and nitrotyrosine formation, appeared to proceed faster when the body temperature was higher. Caspase-3 activation was more pronounced in the hyperthermia group and nuclear translocation of p53 was less pronounced in the hypothermia group 6 h after IR. In the SVZ the loss of nestin-positive progenitors was more pronounced (48%) and the size was smaller (45%) in the hyperthermia group 7 days post-IR. Myelination was not different after hypo- or hyperthermia. This is the first report to demonstrate that hypothermia may be beneficial and that hyperthermia may aggravate the adverse side-effects after radiation therapy to the developing brain.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0022-3042
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
94
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1604-19
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16086699-Animals,
pubmed-meshheading:16086699-Animals, Newborn,
pubmed-meshheading:16086699-Apoptosis,
pubmed-meshheading:16086699-Body Temperature,
pubmed-meshheading:16086699-Brain,
pubmed-meshheading:16086699-Brain Damage, Chronic,
pubmed-meshheading:16086699-Caspase 3,
pubmed-meshheading:16086699-Caspases,
pubmed-meshheading:16086699-Dentate Gyrus,
pubmed-meshheading:16086699-Female,
pubmed-meshheading:16086699-Hyperthermia, Induced,
pubmed-meshheading:16086699-Hypothermia, Induced,
pubmed-meshheading:16086699-Intermediate Filament Proteins,
pubmed-meshheading:16086699-Male,
pubmed-meshheading:16086699-Nerve Degeneration,
pubmed-meshheading:16086699-Nerve Tissue Proteins,
pubmed-meshheading:16086699-Neurons,
pubmed-meshheading:16086699-Radiation, Ionizing,
pubmed-meshheading:16086699-Radiation Injuries, Experimental,
pubmed-meshheading:16086699-Rats,
pubmed-meshheading:16086699-Rats, Wistar,
pubmed-meshheading:16086699-Stem Cells,
pubmed-meshheading:16086699-Tumor Suppressor Protein p53
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Progenitor cell injury after irradiation to the developing brain can be modulated by mild hypothermia or hyperthermia.
|
|
pubmed:affiliation |
The Arvid Carlsson Institute of Neuroscience at the Institute of Clinical Neuroscience, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
