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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-8-9
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pubmed:abstractText |
Vimang is an aqueous extract of Mangifera indica used in Cuba to improve the quality of life in patients suffering from inflammatory diseases. In the present study we evaluated the effects of Vimang at preventing reactive oxygen species (ROS) formation and lipid peroxidation in intact isolated rat hepatocytes. Vimang at 20, 50 and 100 microg/ml inhibited hepatocyte ROS formation induced by glucose-glucose oxidase. Hepatocyte cytotoxicity and lipid peroxidation induced by cumene hydroperoxide was also inhibited by Vimang in a dose and time dependent manner at the same concentration. Vimang also inhibited superoxide radical formation by xanthine oxidase and hypoxanthine. The superoxide radical scavenging and antioxidant activity of the Vimang extract was likely related to its gallates, catechins and mangiferin content. To our knowledge, this is the first report of cytoprotective antioxidant effects of Vimang in cellular oxidative stress models.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Benzene Derivatives,
http://linkedlifedata.com/resource/pubmed/chemical/Gallic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxanthine,
http://linkedlifedata.com/resource/pubmed/chemical/Mangifera indica extract,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Propyl Gallate,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxides,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthine Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/cumene hydroperoxide
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pubmed:status |
MEDLINE
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pubmed:issn |
0792-5077
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19-29
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16086553-Animals,
pubmed-meshheading:16086553-Antioxidants,
pubmed-meshheading:16086553-Benzene Derivatives,
pubmed-meshheading:16086553-Cell Survival,
pubmed-meshheading:16086553-Dose-Response Relationship, Drug,
pubmed-meshheading:16086553-Gallic Acid,
pubmed-meshheading:16086553-Glucose Oxidase,
pubmed-meshheading:16086553-Hepatocytes,
pubmed-meshheading:16086553-Hypoxanthine,
pubmed-meshheading:16086553-Lipid Peroxidation,
pubmed-meshheading:16086553-Male,
pubmed-meshheading:16086553-Mangifera,
pubmed-meshheading:16086553-Oxidants,
pubmed-meshheading:16086553-Oxidative Stress,
pubmed-meshheading:16086553-Plant Extracts,
pubmed-meshheading:16086553-Propyl Gallate,
pubmed-meshheading:16086553-Rats,
pubmed-meshheading:16086553-Rats, Sprague-Dawley,
pubmed-meshheading:16086553-Reactive Oxygen Species,
pubmed-meshheading:16086553-Superoxides,
pubmed-meshheading:16086553-Xanthine Oxidase
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pubmed:year |
2005
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pubmed:articleTitle |
Preventing hepatocyte oxidative stress cytotoxicity with Mangifera indica L. extract (Vimang).
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pubmed:affiliation |
Centro Nacional para el Control Estatal de la Calidad de los Medicamentos, Playa, Habana, Cuba.
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pubmed:publicationType |
Journal Article
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