Source:http://linkedlifedata.com/resource/pubmed/id/16083859
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2005-8-15
|
| pubmed:abstractText |
It has been shown recently that hyperplasia suppressor gene (HSG) is a powerful regulator for cell proliferation and has a critical role in mitochondrial fusion in many cells. However, little is known about its expression, localization, and function during oocyte maturation and early embryogenesis. In this study, with indirect immunofluorescent staining and Western blotting, we found that HSG was expressed in mouse oocytes and preimplantation embryos which primarily exhibited a submembrane distribution pattern in the cytoplasm. Moreover, HSG mainly associated with beta-tubulin during oocyte maturation and early embryonic development. When mouse zygotes were injected with HSG antisense plasmid and cultured in vitro, their capacity to form blastocysts was severely impaired. Our results indicate that HSG plays an essential role in mouse preimplantation development.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0006-291X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
23
|
| pubmed:volume |
335
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
351-5
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16083859-Animals,
pubmed-meshheading:16083859-Blastocyst,
pubmed-meshheading:16083859-Blotting, Western,
pubmed-meshheading:16083859-Cell Proliferation,
pubmed-meshheading:16083859-Cloning, Molecular,
pubmed-meshheading:16083859-Cytoplasm,
pubmed-meshheading:16083859-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:16083859-GTP Phosphohydrolases,
pubmed-meshheading:16083859-Gene Expression Regulation, Developmental,
pubmed-meshheading:16083859-Humans,
pubmed-meshheading:16083859-Mice,
pubmed-meshheading:16083859-Microscopy, Confocal,
pubmed-meshheading:16083859-Microscopy, Fluorescence,
pubmed-meshheading:16083859-Mitochondria,
pubmed-meshheading:16083859-Oligonucleotides, Antisense,
pubmed-meshheading:16083859-Oocytes,
pubmed-meshheading:16083859-Plasmids,
pubmed-meshheading:16083859-Rats,
pubmed-meshheading:16083859-Tubulin
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Expression of HSG is essential for mouse blastocyst formation.
|
| pubmed:affiliation |
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100080, China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|