Linked Life Data

1608313

Source:http://linkedlifedata.com/resource/pubmed/id/1608313

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-7-21
pubmed:abstractText
The influence of the endothelium on the vasodilator effect of ketamine and its possible mechanism of action on intracellular calcium levels were investigated. We conducted experiments in vitro on canine basilar arteries precontracted with 5-HT and with potassium at high concentrations. Ketamine (10(-6) to 10(-3) M), added cumulatively, relaxed both 5-HT and high-K(+)-induced contraction of basilar arteries (with or without endothelium) in a dose-dependent manner. The ED50s of ketamine for relaxation of 5-HT and high-K(+)-induced contraction for intact endothelium were 3 x 10(-4) M and 6 x 10(-4) M, respectively, and for denuded preparations, 7 x 10(-4) M and 15 x 10(-4) M, respectively. Methylene blue, which blocks the release and/or the effect of endothelium derived relaxing factor, significantly attenuated the relaxation effect of ketamine on the basilar artery. Our results indicate that the endothelium may be responsible for a part of the vasodilator effect of ketamine. We also examined the effect of pretreatment of basilar artery with ketamine (5 x 10(-4) M) on intracellular calcium levels when contraction was induced by 5-HT or by high K+ concentrations. Ketamine significantly inhibited the phase of the contraction induced by high K+. Thus, the vasodilator effect of ketamine may be mediated by inhibition of calcium influx and by the release of EDRF.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0254-1319
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Partially endothelium-dependent relaxing effect of ketamine on the canine basilar artery in vitro.
pubmed:affiliation
Department of Anesthesiology, National Defense Medical Center, Taipei, Taiwan, R.O.C.
pubmed:publicationType
Journal Article, In Vitro