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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-8-5
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pubmed:abstractText |
Application of gene therapy to induce antigen-specific immune tolerance could be important for transplantation or treatment of autoimmune diseases. Hematopoietic stem cell-based gene therapy has been hampered by relatively weak gene expression in vivo and loss of transduced cells over time. Selective expansion of transduced hematopoietic stem cells has been accomplished by incorporating the dihydrofolate reductase (DHFR) gene into the gene transfer vector.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0041-1337
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
362-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16082332-Animals,
pubmed-meshheading:16082332-Bone Marrow Cells,
pubmed-meshheading:16082332-Bone Marrow Transplantation,
pubmed-meshheading:16082332-Cell Transplantation,
pubmed-meshheading:16082332-DNA, Complementary,
pubmed-meshheading:16082332-Flow Cytometry,
pubmed-meshheading:16082332-Graft Rejection,
pubmed-meshheading:16082332-Graft Survival,
pubmed-meshheading:16082332-HLA-A2 Antigen,
pubmed-meshheading:16082332-Hematopoietic Stem Cells,
pubmed-meshheading:16082332-Major Histocompatibility Complex,
pubmed-meshheading:16082332-Male,
pubmed-meshheading:16082332-Mice,
pubmed-meshheading:16082332-Mice, Inbred BALB C,
pubmed-meshheading:16082332-Mice, Inbred C57BL,
pubmed-meshheading:16082332-Mice, Transgenic,
pubmed-meshheading:16082332-Mutation,
pubmed-meshheading:16082332-Polymerase Chain Reaction,
pubmed-meshheading:16082332-Retroviridae,
pubmed-meshheading:16082332-Skin Transplantation,
pubmed-meshheading:16082332-Time Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Tolerance by selective in vivo expansion of foreign major histocompatibility complex-transduced autologous bone marrow.
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pubmed:affiliation |
Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198-3285, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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